{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:51:28Z","timestamp":1790808688600,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["setac.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Seven-day sublethal toxicity tests were performed with the freshwater invertebrates Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutus to determine the effects of per- or polyfluorinated alkyl substances (PFAS) of varying chain length within four classes: perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkyl sulfonic acids (PFSAs), perfluoroalkane sulfonamides, and fluorotelomer sulfonic acids. In general, toxicity increased with increasing chain length, but the slopes of these relationships varied markedly by species and chemical class. The toxicity of individual PFCAs was similar among species. The toxicity of PFSAs was similar to PFCAs for C. dubia and H. azteca, whereas PFSAs were much more toxic to C. dilutus, with median effect concentrations (EC50s) as low as 0.022\u2009mg perfluorooctane sulfonate (PFOS)\/L and 0.012\u2009mg perfluorononane sulfonate (PFNS)\/L. Despite the high sensitivity to PFOS and PFNS, C. dilutus was not very sensitive to structurally similar fluorotelomer sulfonates (6:2 and 8:2). Perfluoroalkane sulfonamides were the most toxic class tested among all species (e.g., EC50s of 0.011 and 0.017\u2009mg perfluorooctane sulfonamide\/L for C. dilutus and H. azteca, respectively). The differences in toxicity among species and chemical classes suggest that mechanisms of PFAS toxicity may differ as a function of both. Environ Toxicol Chem 2024;43:359\u2013373. Published 2023. This article is a U.S. Government work and is in the public domain in the USA.<\/jats:p>","DOI":"10.1002\/etc.5784","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T12:26:00Z","timestamp":1699359960000},"page":"359-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Sublethal Toxicity of 17 Per- and Polyfluoroalkyl Substances with Diverse Structures to <i>Ceriodaphnia dubia, Hyalella azteca<\/i>, and <i>Chironomus dilutus<\/i>"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4373-1810","authenticated-orcid":false,"given":"Sarah M.","family":"Kadlec","sequence":"first","affiliation":[{"name":"Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development US Environmental Protection Agency Duluth Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will J.","family":"Backe","sequence":"additional","affiliation":[{"name":"Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development US Environmental Protection Agency Duluth Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-6278","authenticated-orcid":false,"given":"Russell J.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development US Environmental Protection Agency Duluth Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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