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We evaluated alterations in concentrations of the nondestructive biomarkers butyrylcholinesterase (BChE), glutathione-S-transferase (GST), superoxide dismutase (SOD), and reduced glutathione (GSH), together with bioaccumulation of the metals iron (Fe), copper (Cu), zinc (Zn), manganese (Mn), chronium (Cr), aluminium (Al), and lead (Pb) in Caiman latirostris captured in Tapacur\u00e1 Reservoir (TR; S\u00e3o Louren\u00e7o da Mata, Pernambuco, Brasil), in urbanized areas of Pernambuco State (UA; Brasil) and from the AME Brasil caiman farm (AF; Marechal Deodoro, Alagoas, Brasil); the latter was used as a potential reference with low levels of contamination. For metal analysis, 500\u2009\u00b5L of blood was digested in 65% HNO3 and 30% H2O2. The samples were analyzed by inductively coupled plasma\u2013optical emission spectrometry. For analysis of biomarkers, an aliquot of blood was centrifuged to obtain plasma in which biochemical assays were performed. Blood concentrations of metals analyzed in animals from AF were lower compared with TR and UA, confirming that animals from the caiman farm could be used as references with low levels of contamination. Iron, Cu, Mn, Al, and Pb exceeded toxic levels for other vertebrates in animals from TR and UA. Butyrylcholinesterase activity showed significant reduction in adults from UA and TR compared with AF. An increase in the activity of GST and GSH, in adults of TR and UA in relation to AF, was verified. Superoxide dismutase activity showed a significant reduction in adults of TR in relation to AF, and the concentrations of Cu and Mn were negatively correlated with SOD activity. Animals from UA and TR showed greater concentrations of the analyzed metals compared with reference animals, and changes in biomarkers were seen, confirming the potential of these nondestructive chemical and biological parameters in blood of C. latirostris for biomonitoring of pollution. Environ Toxicol Chem 2024;43:878\u2013895. \u00a9 2024 SETAC<\/jats:p>","DOI":"10.1002\/etc.5823","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T13:53:55Z","timestamp":1709042035000},"page":"878-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nondestructive Evaluation of Metal Bioaccumulation and Biochemical Biomarkers in Blood of Broad-Snouted Caiman (<i>Caiman latirostris<\/i>) from Northeastern Brasil"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7180-2228","authenticated-orcid":false,"given":"Rayssa Lima","family":"dos Santos","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Animal Universidade Federal de Pernambuco Recife Brasil"},{"name":"Laborat\u00f3rio Interdisciplinar de Anfibios e R\u00e9pteis, Universidade Federal de Pernambuco Recife Brasil"},{"name":"Laborat\u00f3rio de 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S\u00e1 Leit\u00e3o","family":"Barboza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Interdisciplinar de Anfibios e R\u00e9pteis, Universidade Federal de Pernambuco Recife Brasil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biodiversidade Universidade Federal Rural de Pernambuco Recife Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ednilza Maranh\u00e3o","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biodiversidade, Universidade Federal Rural de Pernambuco, Recife, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joz\u00e9lia Maria","family":"Sousa Correia","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biodiversidade, Universidade Federal Rural de Pernambuco, Recife, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo S\u00e9rgio 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