{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:51:42Z","timestamp":1786121502010,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The number of horses with equine squamous gastric disease (ESGD) and equine gastric glandular disease (EGGD) recurrence when pharmacological treatment is discontinued is high.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine if a commercially available nutraceutical compound containing lecithin, pectin, and meadowsweet could prevent recurrence of both ESGD and EGGD after omeprazole treatment, evaluated by repeated gastroscopic examinations and saliva biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Blinded, randomised, placebo\u2010controlled clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty horses of mixed breeds and sex with a recent diagnosis and treatment of both ESGD and EGGD were included and randomly assigned to a placebo or a nutraceutical group. The horses received 10\u2009mL per 100\u2009kg bodyweight (bwt) of either nutraceutical or placebo orally for the 4\u20138\u2010week duration of the study and were kept in their home environment and trained as normal. Gastroscopic grading of ESGD and EGGD and saliva were obtained at the initial diagnosis, as well as before and after the trial. Salivary biomarkers were measured by automated chemistry analysers using commercial kits. Due to the non\u2010normal distribution of data, Friedman tests with Wilcoxon post hoc tests were applied to assess changes over time within groups, Mann\u2013Whitney U tests were performed to evaluate difference between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Regardless of nutraceutical or placebo assignment, only five horses remained ulcer free after the trial. The nutraceutical was not found to be better than placebo for preventing gastric disease recurrence when evaluated by gastroscopy scores. At the time of the last gastroscopy, the nutraceutical group had lower salivary ADA and higher bicarbonate concentrations compared to the placebo group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Salivary biomarkers need further validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although addition of the nutraceutical did not have a significant effect in preventing ESGD or EGGD recurrence, it produced changes in salivary biomarkers suggesting a potential improvement in gastric mucosal health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/evj.70143","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T05:19:41Z","timestamp":1767158381000},"page":"1191-1198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a nutraceutical for prevention of equine ulcer recurrence"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-3388","authenticated-orcid":false,"given":"Sanni","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences Faculty of Health and Medical Sciences, University of Copenhagen  Taastrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Tecles","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis (Interlab\u2010UMU) Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Joaqu\u00edn","family":"Cer\u00f3n","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis (Interlab\u2010UMU) Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"From","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Faculty of Health and Medical Sciences, University of Copenhagen  Taastrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8952-9637","authenticated-orcid":false,"given":"Helena","family":"Carstensen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Faculty of Health and Medical Sciences, University of Copenhagen  Taastrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mu\u00f1oz\u2010Prieto","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis (Interlab\u2010UMU) Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13071261"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2022.105830"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12491"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12949"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani15030306"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jveb.2022.11.008"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13578"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12287"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1999.tb05176.x"},{"key":"e_1_2_13_11_1","first-page":"79","article-title":"Nutrition and dietary management of equine gastric ulcer syndrome","volume":"25","author":"Reese RE","year":"2009","journal-title":"Vet Clin North Am"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12951"},{"key":"e_1_2_13_13_1","doi-asserted-by":"crossref","unstructured":"ShanR SteelC SykesB.The effects of two different withholding periods of omeprazole on the recurrence of equine gastric ulcer syndrome in thoroughbred racehorses. In: European College of Veterinary Sports Medicine and Rehabilitation Pula Croatia; 2022.","DOI":"10.3390\/ani13111823"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13111823"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2009.08.005"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13091498"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2019.05.007"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776767268"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1999.tb05178.x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102359"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-10-S1-S4"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.942"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.12384"},{"key":"e_1_2_13_24_1","article-title":"Phospholipids: versatile nutraceuticals for functional foods","volume":"12","author":"Kidd PM","year":"2002","journal-title":"Functional Foods Nutraceutical"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516400777584631"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.11.013"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani12233261"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.03.010"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12145_32"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15987"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14030147"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.775"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16795"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215469"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/eve.13458"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2019.102851"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15350"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13223512"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13087"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.1034"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.728"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2024.105346"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776117827"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/evj.70143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/evj.70143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/evj.70143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T05:12:30Z","timestamp":1786079550000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1002\/evj.70143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/evj.70143"],"URL":"https:\/\/doi.org\/10.1002\/evj.70143","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]},"assertion":[{"value":"2025-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}