{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:48:45Z","timestamp":1782388125707,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021853","name":"Horse Trust","doi-asserted-by":"publisher","award":["G2023"],"award-info":[{"award-number":["G2023"]}],"id":[{"id":"10.13039\/501100021853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Information regarding mortality associated with standing procedures in horses is sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report data from &gt;12,000 standing sedations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Confidential, observational, prospective, multicentre, cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected records of horses\/ponies undergoing standing sedation for surgery or advanced diagnostic imaging using at least one top\u2010up or controlled rate infusion (CRI). Procedures were either NON\u2010COLIC or COLIC. Outcome at seven days was recorded as (i) ALIVE, (ii) EUTHANASIA or (iii) DEAD. Data were collected with a portable document format (PDF)\u00a0questionnaire, which evolved into a webpage, and processed with the statistical software R.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data were collected from 12,307 standing sedations in 61 centres in 23 countries. Death rates were 0.15% overall (19\/12,307), 0.13% for NON\u2010COLICs (16\/12,237) and 4.29% for COLICs (3\/70). The causes of death in the 16 NON\u2010COLICs were abdominal complications in 10 (62.50%), fracture\/repeat fracture in three (18.75%), two were \u2018found dead\u2019 (12.50%) and one (6.25%) for \u2018other reasons\u2019. In most cases premedication consisted of combinations of alpha\u20102 agonists\/opioids with or without acepromazine. Sedation was maintained using top\u2010ups (9668\/12,307), CRIs (3795\/12,307) or CRI\u2009+\u2009top\u2010up (1156\/12,307). Detomidine was the alpha\u20102 agonist most frequently used for top\u2010ups (8258\/12,307) and butorphanol the most common opioid (2754\/12,307). Detomidine was the most frequently used alpha\u20102 agonist for CRI (3231\/12,307); 364 and 305\/12,307 received butorphanol and morphine as CRIs, respectively. Only 24.2% received fluid therapy. Loco\u2010regional anaesthesia was performed in 37.6% of the cases. Monitoring was minimal, with temperature (5.8%), electrocardiogram (3.8%), non\u2010invasive arterial pressure (2.1%), end\u2010tidal carbon dioxide (1.1%) and pulse\u2010oximetry (0.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Limitations<\/jats:title>\n                    <jats:p>Sample size, selection bias, questionnaire initially designed for general anaesthesia, potential human errors for data entry and potential missing cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Standing sedation in horses is not risk free. Horses die unexpectedly within seven\u2009days of sedation. Efforts should be made to reduce these mortality rates further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/evj.70183","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:12:58Z","timestamp":1782385978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fatalities within seven\u2009days after equine standing sedation: A prospective, multicentre study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1391-0989","authenticated-orcid":false,"given":"Miguel","family":"Gozalo\u2010Marcilla","sequence":"first","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-9650","authenticated-orcid":false,"given":"Jos\u00e9 I.","family":"Redondo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animal, Facultad de Veterinaria Universidad Cardenal Herrera\u2010CEU, CEU Universities  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1322-3468","authenticated-orcid":false,"given":"Polly M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Taylor Monroe  Little Downham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Domenech","sequence":"additional","affiliation":[{"name":"Departamento de Matem\u00e1ticas, F\u00edsica y Ciencias Tecnol\u00f3gicas, Escuela Superior de Ense\u00f1anzas T\u00e9cnicas Universidad Cardenal Herrera\u2010CEU, CEU Universities  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Dom\u00e9nech","sequence":"additional","affiliation":[{"name":"Freelancer  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon Mark","family":"Johnston","sequence":"additional","affiliation":[{"name":"Vetstream Ltd  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6259-9678","authenticated-orcid":false,"given":"Regula","family":"Bettschart\u2010Wolfensberger","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2025.06.005"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11092549"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2018.08.005"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2004.04.005"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2019.01.005"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2020.08.009"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2005.00098.x"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.14146"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.14192"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516406776563288"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.14137"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.14016"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.882"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235241"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181f44abc"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.4455"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2995.2002.00106.x"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani15131880"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2024.11.005"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2025.04.012"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vaa.12372"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1997.tb03157.x"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2017.03.009"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13054"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.414"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1984.45.02.224"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.b4711"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.70100"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13511"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2018.00204"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00514"},{"key":"e_1_2_14_33_1","first-page":"322","volume-title":"Veterinary Anaesthesia","author":"Hall LW","year":"2013"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.3604"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/vetr.4147"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaa.2022.06.001"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani15152264"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.24.11.0328"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/evj.70183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/evj.70183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/evj.70183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:12:59Z","timestamp":1782385979000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1002\/evj.70183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":37,"alternative-id":["10.1002\/evj.70183"],"URL":"https:\/\/doi.org\/10.1002\/evj.70183","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"2025-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"evj.70183"}}