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Here, a dynamic covalent polymeric antimicrobial, based on phenylboronic acid (PBA)\u2010installed micellar nanocarriers incorporating clinical vancomycin and curcumin, is developed to overcome drug\u2010resistant bacterial infections. The formation of this antimicrobial is facilitated by reversible dynamic covalent interactions between PBA moieties in polymeric micelles and diols in vancomycin, which impart favorable stability in blood circulation and excellent acid\u2010responsiveness in the infection microenvironment. Moreover, the structurally similar aromatic vancomycin and curcumin molecules can afford \u03c0\u2013\u03c0 stacking interaction to realize simultaneous delivery and release of payloads. In comparison with monotherapy, this dynamic covalent polymeric antimicrobial demonstrated more significant eradication of drug\u2010resistant bacteria in vitro and in vivo due to the synergism of the two drugs. Furthermore, the achieved combination therapy shows satisfied biocompatibility without unwanted toxicity. Considering various antibiotics contain diol and aromatic structures, this simple and robust strategy can become a universal platform to combat the ever\u2010threatening drug\u2010resistant infectious diseases.<\/jats:p>","DOI":"10.1002\/exp.20210145","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T05:21:09Z","timestamp":1653283269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["A dynamic covalent polymeric antimicrobial for conquering drug\u2010resistant bacterial infection"],"prefix":"10.1002","volume":"2","author":[{"given":"Fan","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Radiopharmacokinetics for Innovative Drugs Chinese Academy of Medical Sciences, and Institute of Radiation Medicine Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin P. R. 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