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Here, Hydrogenated\u2010silicon nanosheets (H\u2010Si NSs) with favorable biodegradability are integrated and functionalized into a \u03b2\u2010tricalcium phosphate scaffold (H\u2010Si TCP) for bone defect healing. H\u2010Si TCP can greatly improve bone regeneration through osteoimmunomodulation\u2010guided biodegradation in vivo. The spatiotemporal regulation of degradation products replenishes sufficient nutrients step by step for the entire process of bone repair. Extracellular and intracellular reactive oxygen species (ROS) are first downregulated by reaction with H\u2010Si NSs, followed by marked M2 polarization, remodeling the micro\u2010environment timely for immune\u2010bone regeneration. The release of primary reaction products awakened bone marrow mesenchymal stem cells (BMSCs), which are converted into osteoblasts anchored on scaffolds. Subsequently, biomineralization is promoted by the final degradation products. The intrinsic ROS\u2010responsive, immunoregulatory, and osteo\u2010promotive capability of 2D H\u2010Si NSs makes such composite H\u2010Si TCP scaffold a highly potential alternative for the treatment of critical bone defect.<\/jats:p>","DOI":"10.1002\/exp.20220149","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T10:13:52Z","timestamp":1685268832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Hydrogenated silicene nanosheet functionalized scaffold enables immuno\u2010bone remodeling"],"prefix":"10.1002","volume":"3","author":[{"given":"Zixuan","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Microsurgery on Extremities Department of Orthopaedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai P. R. 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