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Initially affecting the hippocampus and entorhinal complex, which are responsible for memory, the disease later impacts the cerebral cortex, controlling language, logic, and social conduct. While the exact cause is unknown, genetic mutations and environmental factors are implicated. Diagnosis involves computed tomography (CT) scans, Magnetic resonance imaging (MRIs), Positron emission tomography (PET) scans, and lumbar punctures to detect brain abnormalities, protein deposits, and cerebrospinal fluid biomarkers. AD features beta\u2010amyloid plaques and neurofibrillary tau tangles that disrupt neuronal function, chronic inflammation, blood\u2010brain barrier impairment, brain atrophy, and neuronal death. There is no cure; current treatments manage symptoms and slow cognitive decline. Research into genetic, cellular, and molecular pathways aims to develop targeted therapies. 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This review discusses the potential of nanotechnology\u2010based therapies to target AD\u2010related tau accumulation and restore normal tau protein mechanics, which could preserve neuronal transmission, synaptic integrity, and brain tissue volume.<\/jats:p>","DOI":"10.1002\/exp.20230137","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T09:14:38Z","timestamp":1718961278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Tau\u2010targeting nanoparticles for treatment of Alzheimer's disease"],"prefix":"10.1002","volume":"5","author":[{"given":"Shreya","family":"Pawar","sequence":"first","affiliation":[{"name":"Use\u2010inspired Biomaterials and Integrated Nano Delivery (U\u2010BiND) Systems Laboratory Department of Pharmaceutical Sciences Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5639-2208","authenticated-orcid":false,"given":"Mohd Ahmar","family":"Rauf","sequence":"additional","affiliation":[{"name":"Use\u2010inspired Biomaterials and Integrated Nano Delivery (U\u2010BiND) Systems Laboratory Department of Pharmaceutical Sciences Wayne State University  Detroit Michigan USA"},{"name":"Department of Surgery Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosam","family":"Abdelhady","sequence":"additional","affiliation":[{"name":"Use\u2010inspired Biomaterials and Integrated Nano Delivery (U\u2010BiND) Systems Laboratory Department of Pharmaceutical Sciences Wayne State University  Detroit Michigan USA"},{"name":"Department of Physiology and Pharmacology Sam Houston State University  Huntsville Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Use\u2010inspired Biomaterials and Integrated Nano Delivery (U\u2010BiND) Systems Laboratory Department of Pharmaceutical Sciences Wayne State University  Detroit Michigan USA"},{"name":"Molecular Imaging Program Karmanos Cancer Institute  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_2_23_2_1","unstructured":"Alzheimer's Disease Fact Sheet https:\/\/www.nia.nih.gov\/health\/alzheimers\u2010disease\u2010fact\u2010sheet(accessed: April 2023)."},{"key":"e_1_2_23_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"e_1_2_23_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.742408"},{"key":"e_1_2_23_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.03.002"},{"key":"e_1_2_23_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.026"},{"key":"e_1_2_23_7_1","unstructured":"Biomarkers for Dementia Detection and Research https:\/\/www.nia.nih.gov\/health\/biomarkers\u2010dementia\u2010detection\u2010and\u2010research(accessed: January2022)."},{"key":"e_1_2_23_8_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14506.1"},{"key":"e_1_2_23_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2020.112238"},{"key":"e_1_2_23_10_1","volume":"32","author":"Karastogiann S.","year":"2020","journal-title":"Biomed. 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