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Here, we developed a nano\u2010silver (Ag)\u2010selenium (Se) liquid dressing (lll) by conjugating Ag and Se nanoparticles with a commercial liquid dressing. After administration to the lesion sites, this unique formulation demonstrated highly effective antiviral properties in a surrogate MPOX mouse model (characterised by skin lesions\/rashes) induced by vaccinia virus infection. In addition, AgSe@LD showed pronounced anti\u2010inflammatory activity and accelerated the healing process of virus\u2010infected cutaneous lesions. Remarkably, AgSe@LD formed a thin film that exhibited excellent adhesion and stability when applied to lesions, while showing resistance to water, alcohol and soapy water washing, thus offering great potential for practical application. This simple and effective liquid dressing represents a major breakthrough in the management of skin infections and provides new ideas for the treatment of MPOX.<\/jats:p>","DOI":"10.1002\/exp.20240253","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:47:32Z","timestamp":1779965252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nano\u2010Silver\u2010Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model"],"prefix":"10.1002","volume":"6","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Institute For Engineering Medicine NHC Key Laboratory of Drug Addiction Medicine Kunming Medical University  Kunming China"},{"name":"BSL\u20103 Laboratory (Guangdong) Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public Health Department of Laboratory 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Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Hainan Medical College Affiliated Danzhou People's Hospital  Danzhou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Infectious Diseases Research in South China (Southern Medical University) Ministry of Education  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyuji","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Chiba University  Chuo\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav Victorovich","family":"Khrustalev","sequence":"additional","affiliation":[{"name":"Department of General Chemistry Belarusian State Medical University  Minsk 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