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To address this challenge, we employed electrotoxic PtRu composite metal nano\u2010berries (PR) loaded with various therapeutic gas donors to construct a groundbreaking electric field\u2010induced cascade gas therapy (EGT) platform, which generated a great electro\u2010stress storm at tumor sites, exerting electrotoxicity and immunity functions against solid tumors, including those of large volume, through three pathways. Initially, electric field stimulation effectively boosted the release rate and yield of therapeutic gases from the EGT platform. Further, gas molecules reacted with reactive oxygen species (ROS) to either form oxidation coordination (CO and ROS) or generate more potent therapeutic components (RNS produced from ROS and NO), contributing to an electro\u2010stress storm that augmented the cytotoxic potential of the gas components. Subsequently, this electro\u2010stress storm further activated the tumor immune response, identifying and capturing escaped tumor cells, which held significant implications for treating tumors, including non\u2010solid tumors with indistinct boundaries. In summary, the EGT platform leveraged an electro\u2010stress storm to achieve ablation of large volume solid tumors and suppressed metastatic tumors, paving new pathways for gas\u2010based therapeutic strategies.<\/jats:p>","DOI":"10.1002\/exp.20240410","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T06:26:17Z","timestamp":1766384777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Groundbreaking Electric Field\u2010Induced Cascade Gas Therapy Against Large Volume Solid Tumor Through Electro\u2010Stress Storm"],"prefix":"10.1002","volume":"5","author":[{"given":"Gui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Dongguan Key Laboratory of Innovative Molecular Imaging, Dongguan Institute of Clinical Cancer Research, The Tenth Affiliated Hospital Southern Medical University (Dongguan People's Hospital) Dongguan P. R. 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