{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:18:15Z","timestamp":1787804295162,"version":"build-2784847793"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471354"],"award-info":[{"award-number":["82471354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171335"],"award-info":[{"award-number":["82171335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060254"],"award-info":[{"award-number":["82060254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277031"],"award-info":[{"award-number":["22277031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Exploration"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The perivascular space (PVS) around cerebral arteries supports nutrient delivery and waste clearance, yet its transport mechanisms remain poorly defined. Here, we establish arterial PVS as a major solute transport route in the brain, exhibiting marked region\u2010specific functionality. Using in vivo imaging, we show that solute movement within arterial PVS is not driven by cerebrospinal fluid (CSF) bulk flow, but follows bidirectional, arterial\u2010pulsation\u2010dependent dynamics. Parenchymal solutes diffuse into the vascular PVS network, where arterial pulsations propel them along perivascular pathways toward capillary and venous compartments to facilitate clearance. Notably, after cortical injection, reduced arterial pulsation and blood flow following carotid ligation significantly increased A\u03b2 retention within arterial PVS. These results define a pulsation\u2010driven perivascular transport system essential for brain solute clearance in health and disease.<\/jats:p>","DOI":"10.1002\/exp.20250264","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:40:22Z","timestamp":1781862022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arterial Perivascular Space\u2010Mediated Solute Transport in the Mouse Brain"],"prefix":"10.1002","volume":"6","author":[{"given":"Shiyong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital of Nanchang University Jiangxi Medical College Nanchang University  Nanchang China"},{"name":"Jiangxi Province Key Laboratory of Neurological Diseases  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital of Nanchang University Jiangxi Medical College Nanchang University  Nanchang China"},{"name":"Jiangxi Province Key Laboratory of Neurological Diseases  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital of Nanchang University Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamei","family":"Yu","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Neurological Diseases  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital of Nanchang University Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Second Affiliated Hospital of Nanchang University Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaelyn V.","family":"Becker","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin \u2010 Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Engle","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin \u2010 Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4072-0075","authenticated-orcid":false,"given":"Dawei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin \u2010 Madison  Madison Wisconsin USA"},{"name":"Department of Nuclear Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-0833","authenticated-orcid":false,"given":"Weibo","family":"Cai","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin \u2010 Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.119"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14432"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142290"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170391"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100227\u20109"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006899\u20104"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220035"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101419\u20105"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100368\u20108"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700999"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20108454\u20101\u20102"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2013"},{"key":"e_1_2_12_14_1","first-page":"153","article-title":"The Connexions of the Spinal Sub\u2010Arachnoid Space with the Lymphatic System","volume":"82","author":"Brierley J. B.","year":"1948","journal-title":"Journal of Anatomy"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591577006300543"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743\u20108454\u20107\u20109"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452169"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2010.04.006"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1592\u201013.2013"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67677"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.09.022"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(25)00115\u20102"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006899\u20104"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27679"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38635"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010018\u20101812\u20104"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax7171"},{"key":"e_1_2_12_29_1","first-page":"193\u2010200","article-title":"The Perivascular Spaces of the Mammalian Central Nervous System and their Relation to the Perineuronal and Subarachnoid Spaces","volume":"89","author":"Woollam D.","year":"1955","journal-title":"Journal of anatomy"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax7171"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201066887\u2010w"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1857"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010019\u20100312\u2010x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02783252"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010022\u201001063\u2010z"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900838"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010024\u201000691\u20103"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04050"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.09.27"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1847"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008\u20106363(96)00134\u20104"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010023\u201001327\u20102"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30318\u20101"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.06.032"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102026\u20101"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/72256"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.04.034"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201007318\u20103"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046329\u20101"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036643\u20105"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010025\u201001977\u20104"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010023\u201001327\u20102"}],"container-title":["Exploration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/EXP.20250264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/EXP.20250264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/EXP.20250264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:23:42Z","timestamp":1787801022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/EXP.20250264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/EXP.20250264"],"URL":"https:\/\/doi.org\/10.1002\/exp.20250264","archive":["Portico"],"relation":{},"ISSN":["2766-8509","2766-2098"],"issn-type":[{"value":"2766-8509","type":"print"},{"value":"2766-2098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"2025-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"20250264"}}