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To overcome this challenge, we developed a microbe\u2010targeted immune reprogramming strategy utilizing tumor cell membrane\u2010camouflaged Ag@MSN\u2010PpIX nanoparticles (M\u2010MAP). Under ultrasound irradiation, M\u2010MAP specifically eliminates intratumoral\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    , thereby directly reversing\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    \u2010mediated immunosuppression while preserving gut microbiota homeostasis. Crucially, the killed\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    acts as an immunostimulant, promoting robust activation of antigen\u2010presenting cells (APCs) and enhancing infiltration of cytotoxic T lymphocytes (CTLs) within the tumor. This dual action\u2014elimination of suppressive bacteria and immunogenic activation by bacterial remnants\u2014effectively reprograms the immunosuppressive tumor microenvironment (TME) in colorectal cancer. This work proposes a therapeutic strategy for cancer that targets tumor\u2010associated bacteria to reprogram the TME, paving the way for more effective cancer treatments.\n                  <\/jats:p>","DOI":"10.1002\/exp.20250551","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:11:06Z","timestamp":1782465066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Elimination of\n                    <i>Fusobacterium nucleatum<\/i>\n                    With Biomimetic Nanoparticles to Reverse Tumor Immunosuppression and Enhance Colorectal Cancer Therapy"],"prefix":"10.1002","volume":"6","author":[{"given":"Mengting","family":"Zhou","sequence":"first","affiliation":[{"name":"Nanotechnology and Intestinal Microecology Research Center, Shanghai Tenth People's Hospital, School of Medicine Tongji University  Shanghai China"},{"name":"Affiliated Suzhou Hospital of Nanjing Medical 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