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To overcome this limitation, we developed a radiolabeled coordination polymer,\n                    <jats:sup>177<\/jats:sup>\n                    Lu\u2010GAMP, through the self\u2010assembly of\n                    <jats:sup>177<\/jats:sup>\n                    Lu\n                    <jats:sup>3+<\/jats:sup>\n                    with adenosine monophosphate (AMP) and guanosine monophosphate, exhibiting coordination\u2010feature resemblance to the endogenous STING agonist cGAMP, thereby enabling activation of the STING pathway. We further incorporated\n                    <jats:sup>177<\/jats:sup>\n                    Lu\u2010GAMP into a dissolvable microneedle patch (\n                    <jats:sup>177<\/jats:sup>\n                    Lu\u2010GAMP@MN) for localized, minimally invasive delivery to melanoma lesions. Our results demonstrate that\n                    <jats:sup>177<\/jats:sup>\n                    Lu\u2010GAMP@MN effectively penetrated the skin and retained at the tumor site, leading to robust STING activation and Gasdermin E\u2010mediated pyroptosis. This, in turn, promoted dendritic cell maturation and enhanced T cell infiltration. In vivo,\n                    <jats:sup>177<\/jats:sup>\n                    Lu\u2010GAMP@MN significantly suppressed subcutaneous melanoma growth, prolonged survival, and elicited strong antitumor immune responses. When combined with anti\u2010PD\u2010L1 monoclonal antibodies, the treatment achieved synergistic tumor regression, improved effector T cell function, and induced durable immunological memory, demonstrating significant inhibition of both primary and distant tumors in murine models. Collectively, this work presents a transdermal brachytherapeutic\u2010immunomodulatory strategy for melanoma treatment, offering promising potential for enhanced antitumor immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/exp.20250737","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:52:12Z","timestamp":1782118332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiolabeled Coordination Polymer\u2010Loaded Microneedles for Synergistic Melanoma Brachytherapy\u2013Immunotherapy via STING Activation and Pyroptosis"],"prefix":"10.1002","volume":"6","author":[{"given":"Pian","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  Changsha China"},{"name":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and Disease Xiangya Hospital  Changsha China"},{"name":"Furong Labratory  Changsha China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Medical Physics University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Li","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and Disease Xiangya Hospital  Changsha China"},{"name":"Furong Labratory  Changsha China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxuan","family":"Yan","sequence":"additional","affiliation":[{"name":"The Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis Hunan Engineering Research Center of Skin Health and Disease Xiangya Hospital  Changsha China"},{"name":"Furong Labratory  Changsha China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 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