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We fabricated an ingenious redox\u2010responsive strategy for commanded liberation of NADH (reduced form of nicotinamide\u2010adenine dinucleotide) by bioactive diselenide\u2010containing biodegradable mesoporous silica nanoparticles (\n                    <jats:bold>Se@NADH<\/jats:bold>\n                    ). The nanocarrier\u2010embedded NADH can be liberated in a controlled pattern through the cleavage of diselenide bonds in the presence of reactive oxygen species (ROS) or glutathione (GSH). The NAD\n                    <jats:sup>+<\/jats:sup>\n                    was regenerated by the reactions between released NADH and harmful ROS to antagonize mitochondrial dysfunction and increase ATP synthesis, promoting axon regeneration across SCI areas. This nanosystem increased the stability of NADH during prolonged blood circulation time, reduced the clearance rate, exhibited significant anti\u2010inflammatory as well as neuroprotective effects and enhanced the regeneration of electrophysiological conduction capacity across SCI areas. Importantly,\n                    <jats:bold>Se@NADH<\/jats:bold>\n                    suppressed glial scar formation and promoted neuronal generation as well as stretching of long axons throughout the glial scar, thereby improving actual restoration of locomotor functions in mice with SCI and exerting ascendant therapeutic effects. Targeting of mitochondrial dysfunction is a potential approach for SCI treatment and may be applied to other central nervous system diseases.\n                  <\/jats:p>","DOI":"10.1002\/exp.70012","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T01:34:59Z","timestamp":1738892099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Dual\u2010Responsive Multi\u2010Functional Silica Nanoparticles With Repaired Mitochondrial Functions for Efficient Alleviation of Spinal Cord Injury"],"prefix":"10.1002","volume":"5","author":[{"given":"Guibin","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Dermatology, Guangdong Provincial Key Laboratory of Allergy &amp; Immunology The Second Affiliated Hospital of Guangzhou Medical University Guangdong Key Laboratory of Urology and Department of Urology The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangzhou Institute of Cancer Research The Affiliated Cancer Hospital and School of Biomedical Engineering Guangzhou Medical University  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Guangdong Provincial Key Laboratory of Allergy &amp; Immunology The Second Affiliated Hospital of Guangzhou Medical University Guangdong Key Laboratory of Urology and Department of Urology The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangzhou Institute of Cancer Research The Affiliated Cancer Hospital and School of Biomedical Engineering Guangzhou Medical University  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Ma","sequence":"additional","affiliation":[{"name":"Honghui Hospital Xi'an Jiaotong University  Xi'an City 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