{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:26:16Z","timestamp":1793579176606,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2026GXNSFGA00640007"],"award-info":[{"award-number":["2026GXNSFGA00640007"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573556"],"award-info":[{"award-number":["82573556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473348"],"award-info":[{"award-number":["82473348"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303797"],"award-info":[{"award-number":["82303797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFB638"],"award-info":[{"award-number":["2024AFB638"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Exploration"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Manganese oxide (MnO\n                    <jats:sub>x<\/jats:sub>\n                    ) nanozymes have garnered significant attention for their ability to respond to the tumor microenvironment (TME) and stimulator of interferon genes (STING) pathway activation. However, they often suffer from a weak direct tumor\u2010killing capacity due to low enzymatic activity and from attenuated anti\u2010tumor immunity resulting from STING activation\u2010induced excessive programmed death\u2010ligand 1 (PD\u2010L1) expression. In this study, we fabricated MnO\n                    <jats:sub>x<\/jats:sub>\n                    nanozymes with precisely controllable valence states via electrochemical valence regulation to modulate their oxidase\u2010like activity. Notably, M\u2010MnOx, with a bulk Mn oxidation state of +3.62, a near\u2010surface Mn oxidation state of approximately +3.23, 19.1% oxygen vacancies, and a reduced Mn\u2212O coordination number of 4.7, exhibited the highest oxidase\u2010like activity and was therefore selected for cancer therapy. This nanozyme was subsequently wrapped with a T lymphocyte membrane (TCM) to form biomimetic nanozymes (TMO). TMO efficiently targets tumors and induces immunogenic cell death via oxidase catalytic therapy, while also activating the cGAS\u2010STING pathway and T cells for tumor killing. Furthermore, TMO competitively binds to tumor cell highly expressed PD\u2010L1 to alleviate T cell immune suppression. Consequently, TMO demonstrates excellent tumor\u2010killing efficacy and inhibits recurrence in vivo. This research offers a new perspective for the construction of manganese\u2010based nanomaterials.\n                  <\/jats:p>","DOI":"10.1002\/exp2.70224","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:00:28Z","timestamp":1789704028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrochemical Valence\u2010Regulated Biomimetic Nanozymes for Breast Cancer Metabolism Inhibition and Potentiated Catalytic Immunotherapy"],"prefix":"10.1002","volume":"6","author":[{"given":"You","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Breast Surgery The Second Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiology Tongji Hospital, Tongji Medical College, Huazhong University of Science and 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