{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:50:18Z","timestamp":1791521418951,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373871"],"award-info":[{"award-number":["82373871"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974508"],"award-info":[{"award-number":["81974508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["202045005"],"award-info":[{"award-number":["202045005"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","award":["2024JK2114"],"award-info":[{"award-number":["2024JK2114"]}],"id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Exploration"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Targeting soluble neurosensitizers in the osteoarthritis (OA) joint cavity is a key strategy for alleviating OA pain. Soluble neurosensitizers are ubiquitous in the joint cavity and cause uncontrollable growth and sensitization of nociceptor axons therein. However, eliminating these soluble nerve growth factors (NGFs) remains a considerable challenge due to the diversity of neurosensitizers and the complexity of OA pathology. This study introduces an innovative soluble nanodrug (LAC)\u2010based strategy to eliminate three key neurosensitizers (H\n                    <jats:sup>+<\/jats:sup>\n                    , NGF, and netrin\u20101) to simultaneously relieve OA\u2010associated pain and joint damage. In two animal model experiments, LAC significantly reduced pain and alleviated OA progression by reducing synovial inflammation and inhibiting cartilage and subchondral bone damage. This strategy of using soluble nanomedicine to counter soluble neurosensitizers not only provides inspiration for eliminating pain, but also sheds light on possible solutions for advancing OA treatment strategies.\n                  <\/jats:p>","DOI":"10.1002\/exp2.70233","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:25:42Z","timestamp":1791519942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Soluble Nanomedicine Against Soluble Neurosensitizers to Effectively Relieve Osteoarthritis Pain and Joint Damage"],"prefix":"10.1002","author":[{"given":"Junyan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The Third Xiangya Hospital Central South University  Changsha China"},{"name":"Department of Orthopaedics Xiangya Hospital Central South University  Changsha 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Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Xiangya Hospital Central South University  Changsha China"},{"name":"Key Laboratory of Aging\u2010Related Bone and Joint Diseases Prevention and Treatment Ministry of Education Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Joint Degeneration and Injury  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelong","family":"Ai","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 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