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A crucial goal is to hinder this progression. In a recent clinical trial involving 14 FAP patients, half received 60\u00a0g of black raspberry (BRB) powder orally and BRB suppositories at bedtime, whereas the other half received only BRB suppositories at bedtime over 9 months. This intervention led to a notable reduction in rectal polyps for 11 patients, although 3 showed no response. In this study, we delved into the metabolic changes induced by BRBs in the same patient cohort. Employing mass spectrometry\u2013based non\u2010targeted metabolomics, we analyzed pre\u2010 and post\u2010BRB urinary and plasma samples from the 11 responders. The results showed significant alterations in 23 urinary and 6 plasma metabolites, influencing various pathways, including polyamine, glutathione metabolism, the tricarboxylic acid cycle, inositol metabolism, and benzoate production. BRBs notably elevated levels of several metabolites associated with these pathways, suggesting a potential mechanism through which BRBs facilitate rectal polyp regression in FAP patients by modulating multiple metabolic pathways. Notably, metabolites derived from BRB polyphenols were significantly increased post\u2010BRB intervention, emphasizing the potential therapeutic value of BRBs in FAP management.<\/jats:p>","DOI":"10.1002\/fft2.323","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T03:10:27Z","timestamp":1706497827000},"page":"259-266","source":"Crossref","is-referenced-by-count":1,"title":["Black raspberry\u2013mediated metabolic changes in patients with familial adenomatous polyposis associated with rectal polyp regression"],"prefix":"10.1002","volume":"5","author":[{"given":"Yi\u2010Wen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010zhi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro\u2010products, Key Laboratory of Post\u2010Harvest Fruit Processing, Key Laboratory of Post\u2010Harvest Vegetable Preservation and Processing, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fruit and Vegetable Preservation and Processing Technology of Zhejiang Province, Key Laboratory of Light Industry Fruit and Vegetable Preservation and Processing, Institute of Food Science Zhejiang Academy of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Niu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro\u2010products, Key Laboratory of Post\u2010Harvest Fruit Processing, Key Laboratory of Post\u2010Harvest Vegetable Preservation and Processing, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fruit and Vegetable Preservation and Processing Technology of Zhejiang Province, Key Laboratory of Light Industry Fruit and Vegetable Preservation and Processing, Institute of Food Science Zhejiang Academy of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro\u2010products, Key Laboratory of Post\u2010Harvest Fruit Processing, Key Laboratory of Post\u2010Harvest Vegetable Preservation and Processing, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fruit and Vegetable Preservation and Processing Technology of Zhejiang Province, Key Laboratory of Light Industry Fruit and Vegetable Preservation and Processing, Institute of Food Science Zhejiang Academy of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3545-4224","authenticated-orcid":false,"given":"Haiyan","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro\u2010products, Key Laboratory of Post\u2010Harvest Fruit Processing, Key Laboratory of Post\u2010Harvest Vegetable Preservation and Processing, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fruit and Vegetable Preservation and Processing Technology of Zhejiang Province, Key Laboratory of Light Industry Fruit and Vegetable Preservation and Processing, Institute of Food Science Zhejiang Academy of..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, Comprehensive Cancer Center City of Hope National Medical Center  Duarte California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6500-6943","authenticated-orcid":false,"given":"Li\u2010Shu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology and 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