{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T23:10:13Z","timestamp":1699053013046},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T00:00:00Z","timestamp":1161216000000},"content-version":"vor","delay-in-days":11249,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nahrung"],"published-print":{"date-parts":[[1976,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Unter Anwendung eines fr\u00fcher beschriebenen Pr\u00fcfungssystems wurde mit Hilfe von 131\u2010J\u2010Na J die Wirkung von t\u00e4glich 30 und 75 mg DDT\/kg KG sowie t\u00e4glich 12 und 36 mg Lindan\/kg KG auf den Jod\u2010 bzw. Hormonstoffwechsel von Ratten untersucht. Beim DDT konnte eine deutliche Erh\u00f6hung der Schilddr\u00fcsen(SD)\u2010Masse sowie des T3 und T4<jats:sup>2<\/jats:sup> der SD bei gleichzeitiger Senkung des SD\u2010J beobachtet werden; Serum\u2010J und \u2010PBJ<jats:sup>2<\/jats:sup> waren vermindert, \u2010T4 schwach, \u2010T<jats:sub>3<\/jats:sub> deutlich erh\u00f6ht, das letzte gilt auch f\u00fcr die J\u2010Fraktionen der Leber.<\/jats:p><jats:p>Lindan zeigte erheblich geringere Wirkungen. Auffallend war hier lediglich eine Senkung des SD\u2010T<jats:sub>3<\/jats:sub> bei gleichzeitiger Steigerung des SD\u2010T4. Im Serum waren beide Hormone etwas vermehrt. Die Werte der Urinfraktionen deuten bei beiden Wirkstoffen auf eine Hypofunktion. Die Ursachen der beobachteten Ver\u00e4nderungen werden im Zusammenhang mit den Feststellungen anderer Autoren diskutiert. Aus den Beobachtungen ergibt sich, da\u00df die Wirkungen der untersuchten Pestizide auf die Schilddr\u00fcsenfunktion offensichtlich vielschichtig sind.<\/jats:p>","DOI":"10.1002\/food.19760200412","type":"journal-article","created":{"date-parts":[[2006,11,3]],"date-time":"2006-11-03T05:38:52Z","timestamp":1162532332000},"page":"399-406","source":"Crossref","is-referenced-by-count":1,"title":["Zur Wirkung von DDT und Lindan auf die Schilddr\u00fcsenfunktion der Ratte"],"prefix":"10.1002","volume":"20","author":[{"given":"H.","family":"Seidler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"H\u00e4rtig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Engst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/food.19750190813"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1139\/y68-010"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.166.3910.1278"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9327(71)90006-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01559078"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01684474"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01684561"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0530125"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-143-37281"},{"key":"e_1_2_1_11_2","first-page":"94","volume-title":"Fermente, Hormone, Vitamine","author":"Ammon R.","year":"1960"}],"container-title":["Food \/ Nahrung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ffood.19760200412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/food.19760200412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T22:40:43Z","timestamp":1699051243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/food.19760200412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1976,1]]}},"alternative-id":["10.1002\/food.19760200412"],"URL":"https:\/\/doi.org\/10.1002\/food.19760200412","archive":["Portico"],"relation":{},"ISSN":["0027-769X","1521-3803"],"issn-type":[{"value":"0027-769X","type":"print"},{"value":"1521-3803","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,1]]}}}