{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T12:10:28Z","timestamp":1698149428944},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T00:00:00Z","timestamp":1161216000000},"content-version":"vor","delay-in-days":5770,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nahrung"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Die Wirkungen eines Fetts\u00e4uregemisches mit einem Gehalt an ungeradzahligen Fetts\u00e4uren von ann\u00e4hernd 50 % (PC\u2010S\u00e4ure) wurden in einem subchronischen Toxizit\u00e4tsversuch mit m\u00e4nnlichen und weiblichen Ratten untersucht. Die Tiere erhielten PC\u2010S\u00e4ure mit dem Futter in Beimengungen von 0; 1,25; 2,5 und 5 % \u00fcber einen Zeitraum von 13 Wochen. Die Futteraufnahme war bei den M\u00e4nnchen mit 5 % PC\u2010S\u00e4ure erh\u00f6ht. Die Futterverwertung war anf\u00e4nglich in dieser Gruppe bei M\u00e4nnchen und Weibchen verringert. Die Aufnahme von PC\u2010S\u00e4ure resultierte bei beiden Geschlechtern in einem Anstieg des Harnvolumens und der Aktivit\u00e4t der Lactatdehydrogenase im Harn. Mit PC\u2010S\u00e4ure gef\u00fctterte m\u00e4nnliche und weibliche Ratten zeigten im Serum erh\u00f6hte Aktivit\u00e4ten der alkalischen Phosphatase und Leucinaminopeptidase und verminderte Cholesterol\u2010 und Triglyceridkonzentrationen. PC\u2010S\u00e4ure erh\u00f6hte den Serumkreatiningehalt bei den M\u00e4nnchen mit den beiden h\u00f6chsten Beimengungen. Eine zwischenzeitliche Erh\u00f6hung der Alaninaminotransferaseaktivit\u00e4t im Serum wurde bei den Weibchen mit 5 % PC\u2010S\u00e4ure beobachtet. Leber\u2010 und Nierenmassenzunahmen traten bei beiden Geschlechtern auf.<\/jats:p>","DOI":"10.1002\/food.19910350509","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T19:45:05Z","timestamp":1162496705000},"page":"465-474","source":"Crossref","is-referenced-by-count":0,"title":["Toxikologische Wirkungen eines Fetts\u00e4uregemisches bei Ratten"],"prefix":"10.1002","volume":"35","author":[{"given":"H.\u2010J.","family":"Lewerenz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W. R.","family":"Bleyl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Ozierenski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Plass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Macholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,19]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"De Groot A. P. in: Proceedings of the Regional Seminar on Microbial Conversion Systems for Food and Fodder Production and Waste Management. Herausgegeben von T. G. Overmire. S.133\u2013143. Kuwait1977."},{"key":"e_1_2_1_3_2","first-page":"2","volume":"4","author":"Kapsiotis G. D.","year":"1978","journal-title":"Food Nutrit."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-46540-6"},{"key":"e_1_2_1_5_2","unstructured":"Amtsblatt der EG: ABL Nr. 1. 217\/27 vom 14.8.1985."},{"key":"e_1_2_1_6_2","first-page":"405","volume":"14","author":"Bernardini N. P.","year":"1976","journal-title":"Nutrit. Rep. Int."},{"key":"e_1_2_1_7_2","first-page":"125","volume":"17","author":"Bernardini M. P.","year":"1978","journal-title":"Nutrit. Rep. Int."},{"key":"e_1_2_1_8_2","first-page":"137","volume":"17","author":"Bernardini M. P.","year":"1978","journal-title":"Nutrit. Rep. Int."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-023765-7.50012-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-023765-7.50016-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(80)90065-X"},{"key":"e_1_2_1_12_2","first-page":"147","volume":"17","author":"Bernardini M. P.","year":"1978","journal-title":"Nutrit. Rep. Int."},{"key":"e_1_2_1_13_2","first-page":"357","volume":"17","author":"Gozzo S.","year":"1978","journal-title":"Nutrit. Rep. Int."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-6264(82)80001-1"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.2570030303"},{"key":"e_1_2_1_16_2","volume-title":"Klinische Chemie und Mikroskopie. Ausgew\u00e4hlte Untersuchungsmethoden f\u00fcr des medizinisch\u2010klinische Laboratorium","author":"Hallmann L.","year":"1980"},{"key":"e_1_2_1_17_2","volume-title":"Diagnostische Laboratoriumsmethoden (AB(D.L.)\u2010DDR)","author":"Arzneibuch der DDR","year":"1983"},{"key":"e_1_2_1_18_2","volume-title":"Untersuchungen von Blut und Knochenmark","author":"Stobbe H.","year":"1977"},{"key":"e_1_2_1_19_2","first-page":"41","volume":"26","author":"Neth R.","year":"1980","journal-title":"\u00c4ral. Lab."},{"key":"e_1_2_1_20_2","volume-title":"Klinische Chemie","author":"Richterich R.","year":"1968"},{"key":"e_1_2_1_21_2","volume-title":"Methoden der enzymatischen Analyse","author":"Bergmeyer H. U.","year":"1962"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00326644"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(87)90300-0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(71)90180-2"},{"key":"e_1_2_1_25_2","first-page":"470","volume-title":"Biochemische Befunde in der Differentialdiagnose innerer Krankheiten","author":"S\u00fcdhof H.","year":"1975"},{"key":"e_1_2_1_26_2","first-page":"1","volume-title":"Toxicology of the Liver","author":"Zimmermann H. J.","year":"1982"},{"key":"e_1_2_1_27_2","first-page":"3.95","volume-title":"Klinische Hepatologie","author":"Schmidt F. W.","year":"1979"},{"key":"e_1_2_1_28_2","first-page":"286","volume-title":"Casarett and Doull's Toxicology, The basic science of poisons","author":"Plaa G. L.","year":"1986"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/food.19910350708"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/food.19910350514"}],"container-title":["Food \/ Nahrung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ffood.19910350509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/food.19910350509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:32:11Z","timestamp":1698042731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/food.19910350509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1002\/food.19910350509"],"URL":"https:\/\/doi.org\/10.1002\/food.19910350509","archive":["Portico"],"relation":{},"ISSN":["0027-769X","1521-3803"],"issn-type":[{"value":"0027-769X","type":"print"},{"value":"1521-3803","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}