{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:28:51Z","timestamp":1785540531586,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Camellia sinensis<\/jats:italic> (L.) O. Kuntze cv. CFT\u20101 is an elite tea variety bred by sexual hybridization with a high content of epigallocatechin\u20103\u2010gallate (EGCG) as 134.2\u00a0mg\/g (which is 2.54\u2010fold that of the common variety). This study was to evaluate the chemopreventive effects of CFT\u20101 green tea infusion (CFT\u20101) against <jats:italic>N<\/jats:italic>\u2010nitrosodiethylamine (NDEA)\u2010induced hepatocarcinogenesis in rats and its mechanisms. The results showed that CFT\u20101 had a superior inhibitory effect in NDEA\u2010initiated hepatocarcinogenesis compared to that of common tea. CFT\u20101 significantly reduced the hepatic nodules incidence, size, and number and prevented the hepatic adenoma or hepatocellular carcinoma (HCC) formation. In particular, CFT\u20101\u2010treated animals had the least incidence of HCC (8.33%) followed by common tea treatment (40.00%) and model control rats (87.50%). CFT\u20101 treatment significantly ameliorated abnormal liver function enzymes, reduced serum AFP, CEA, TSGF, and TNF\u2010\u03b1 levels, inhibited the dickkopf\u2010related protein\u20101 expression, enhanced antioxidant capacity, suppressed the production of livers 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine, and regulated hepatic phase I and II xenobiotic\u2010metabolizing enzymes. Transcriptomic analysis of liver tissue suggested that compared to common tea, administration of CFT\u20101 regulated larger gene sets, which were located in several important pathways of antioxidants, inflammatory network, xenobiotic\u2010metabolizing enzymes, apoptosis, cell proliferation, and metabolism associated with liver tumorigenesis. We identified some genes as potential molecular targets involved in the prevention of CFT\u20101 and found that CFT\u20101 inhibited inflammation response, proliferation, and accelerated apoptosis by inhibiting NF\u2010\u03baB and PI3K\/Akt pathway. Thus, EGCG\u2010rich CFT\u20101 green tea might be a potential choice for liver cancer prevention\/treatment in the future.<\/jats:p>","DOI":"10.1002\/fsn3.1121","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T04:15:22Z","timestamp":1562300122000},"page":"2647-2665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Chemoprevention of elite tea variety CFT\u20101 rich in EGCG against chemically induced liver cancer in rats"],"prefix":"10.1002","volume":"7","author":[{"given":"Sufeng","family":"Liao","sequence":"first","affiliation":[{"name":"Agricultural Product Quality Institute Fujian Agriculture and Forestry University Fuzhou China"},{"name":"Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops, College of Crop Science Fujian Agriculture and Forestry University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinke","family":"Lin","sequence":"additional","affiliation":[{"name":"Anxi College of Tea Science Fujian Agriculture and Forestry University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Agricultural Product Quality Institute Fujian Agriculture and Forestry University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuansheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Hospital of Fujian Agriculture and Forestry University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fujian Province for Crop Biotechnology Fujian Agriculture and Forestry University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4976-9024","authenticated-orcid":false,"given":"Jingui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Agricultural Product Quality Institute Fujian Agriculture and Forestry University Fuzhou China"},{"name":"Key Laboratory of Ministry of Education for Genetics, Breeding and Multiple Utilization of Crops, College of Crop Science Fujian Agriculture and Forestry University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"topGO: Enrichment analysis for gene ontology. 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