{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:34:02Z","timestamp":1767904442158,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003668","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","award":["316006\u201005\u20101\u2010HD040"],"award-info":[{"award-number":["316006\u201005\u20101\u2010HD040"]}],"id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As one of the wide\u2010ranging form of chronic liver disease, there are only limited therapeutic options for nonalcoholic fatty liver disease (NAFLD). We evaluated whether fermented black radish (<jats:italic>Raphanus sativus<\/jats:italic> L. var. <jats:italic>niger<\/jats:italic>; FBR) ameliorates lipid accumulation, inflammation, and hepatic fibrosis, which are characteristics of the pathogenesis of NAFLD. Fermented black radish treatment reduced lipid accumulation in 3T3\u2010L1 adipocytes, which appeared to be associated with the downregulation of adipogenic transcription factors, including sterol regulatory element\u2010binding protein 1c, CCAAT\/enhancer\u2010binding protein \u03b1, peroxisome proliferator\u2010activated receptor \u03b3, and lipid accumulation\u2010related genes including adipocyte protein\u20102 and fatty acid synthase. Administration of FBR to C57BL\/6J mice challenged with methionine and choline deficient (MCD) diet significantly attenuated the increased serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and triglyceride. In addition, treatment with FBR interestingly repressed the hepatic inflammation induced with MCD diet, by lowering the expression of inducible nitric oxide synthase and suppressing the inactivation of macrophages and Kupffer cells in the liver. Fermented black radish was also shown to mitigate liver fibrosis through the inhibition of alpha\u2010smooth muscle actin, transforming growth factor beta\u20101, and collagen type I alpha 1 chain. Our results indicate that FBR ameliorates NAFLD and its related metabolic disease by regulating multiple pathways, suggesting that FBR may be an effective dietary supplement for ameliorating NAFLD.<\/jats:p>","DOI":"10.1002\/fsn3.1200","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T15:48:01Z","timestamp":1568044081000},"page":"3327-3337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fermented black radish (<i>Raphanus sativus<\/i> L. var. <i>niger<\/i>) attenuates methionine and choline deficient diet\u2010induced nonalcoholic fatty liver disease in mice"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7302-9694","authenticated-orcid":false,"given":"Meejung","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research Institute Jeju National University Jeju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2238-1038","authenticated-orcid":false,"given":"Jeongtae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research Institute Jeju National University Jeju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-2409","authenticated-orcid":false,"given":"Yuna","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research Institute Jeju National University Jeju Republic of 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