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Although lymphomas can be effectively treated with chemotherapy, this approach is associated with the risk of adverse side effects. High intake of certain vegetables and fruits is associated with a reduced risk of cancer development. We hypothesized that Annona fruit, which is rich in fibers and phytochemicals that are known to possess anticancer properties, can be effective in inhibiting lymphoma growth. The Annona fruit's fractions were extracted with water, methanol, or chloroform and then assayed for total phenolic, flavonoids, and tannins content; antioxidation activities; and inhibition of in vitro cell proliferation using the Ramos\u20101 lymphoma cells. The methanol fractions contained the highest phenolics, flavonoids, and tannins content, and antioxidation activity. However, the methanol extracts of skin, pulp, and seeds had a moderate whereas the chloroform extracts of pulp and seeds had strong effects on Ramos\u20101 cell proliferation. Our findings suggest that Annona fruits may be effective in the prevention or treatment of lymphoma.<\/jats:p>","DOI":"10.1002\/fsn3.1228","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:20:46Z","timestamp":1575282046000},"page":"58-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Phytochemical profile and antioxidation activity of annona fruit and its effect on lymphoma cell proliferation"],"prefix":"10.1002","volume":"8","author":[{"given":"Huda Mohammed","family":"Al\u2010Shaya","sequence":"first","affiliation":[{"name":"Food Chemistry and Nutrition Science Research Laboratory Virginia State University Petersburg Virginia"},{"name":"Department of Biology College of Natural and Health Sciences Virginia State University Petersburg Virginia"},{"name":"Princess Nourah Bint Abdulrahman University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Food Chemistry and Nutrition Science Research Laboratory Virginia State University Petersburg Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Obaid U.","family":"Beg","sequence":"additional","affiliation":[{"name":"Food Chemistry and Nutrition Science Research Laboratory Virginia State University Petersburg Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar A.","family":"Hamama","sequence":"additional","affiliation":[{"name":"Common Research Laboratory Agricultural Research Station College of Agriculture Virginia State University Petersburg Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Melissa","family":"Witiak","sequence":"additional","affiliation":[{"name":"Department of Biology College of Natural and Health Sciences Virginia State University Petersburg Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kaseloo","sequence":"additional","affiliation":[{"name":"Department of Biology College of Natural and Health Sciences Virginia State University Petersburg Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-940X","authenticated-orcid":false,"given":"Rafat A.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Food Chemistry and Nutrition Science Research Laboratory Virginia State University Petersburg Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,30]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Cancer facts & figures 2018","author":"ACS","year":"2018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(12)60042-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-2923-0_16"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.06.044"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/439456"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5772\/33651"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:QUAL.0000040268.06587.2a"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1902"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.9.2368"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31407"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji293"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0611668"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8010028"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2016.01.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2011.0303"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2015.10.002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428191003690364"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00235-1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0031"},{"issue":"2","key":"e_1_2_8_25_1","first-page":"103","article-title":"Long\u2010term toxicity of chemotherapy and radiotherapy in lymphoma survivors: Optimizing treatment for individual patients","volume":"13","author":"Hodgson D. 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