{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:41Z","timestamp":1786977761823,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T00:00:00Z","timestamp":1573948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Insect tea is a traditional Chinese drink that contains abundant bioactive substances. In this study, the preventive effect of Insect tea on D\u2010galactose\u2010induced oxidation in mice was studied. The serum, liver, and spleen of mice were measured by biochemical and molecular biological methods, which showed that Insect tea could increase the biochemical indexes of the thymus, brain, heart, liver, spleen, and kidney in mice with induced oxidative damage. Insect tea can increase the levels of SOD (superoxide dismutase), GSH\u2010Px (glutathione peroxidase), and GSH (glutathione) and decrease the levels of MDA (malondialdehyde) in the serum, liver, and spleen of mice with oxidative damage. Pathological observation also confirmed that Insect tea could inhibit oxidative damage of the liver and spleen tissue caused by D\u2010galactose in mice. Further molecular biological experiments also showed that Insect tea could upregulate the mRNA and protein expression of Cu\/Zn\u2010SOD (cuprozinc\u2010superoxide dismutase), Mn\u2010SOD (manganese superoxide dismutase), CAT (catalase), HO\u20101 (heme oxygenase\u20101), Nrf2 (nuclear factor\u2010erythroid 2 related factor 2), \u03b3\u2010GCS (\u03b3\u2010glutamylcysteine synthetase), and NQO1 (NAD(P)H dehydrogenase [quinone] 1) in the liver and spleen of oxidized mice. Insect tea has a good preventive effect on D\u2010galactose\u2010induced oxidation in mice, and the effect is better than vitamin C, an antioxidant. Insect tea is rich in isochlorogenic acid A, quercetin, rutin, hesperidin, neochlorogenic acid, and cryptochlorogenic acid. The combination of these bioactive substances has good antioxidant effects. Thus, Insect tea is a functional food with a good antioxidant effect that has value for future development and utilization.<\/jats:p>","DOI":"10.1002\/fsn3.1278","type":"journal-article","created":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T22:45:04Z","timestamp":1574030704000},"page":"4105-4115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of insect tea on D\u2010galactose\u2010induced oxidation in mice and its mechanisms"],"prefix":"10.1002","volume":"7","author":[{"given":"Kai","family":"Zhu","sequence":"first","affiliation":[{"name":"Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing China"},{"name":"Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing China"},{"name":"Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The First Affiliated Hospital of Chengdu Medical College Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Public Health Our Lady of Fatima University Valenzuela Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology Yangtze Normal University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing China"},{"name":"Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing China"},{"name":"Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Song","sequence":"additional","affiliation":[{"name":"Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing China"},{"name":"Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing China"},{"name":"Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-7865","authenticated-orcid":false,"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.08.038"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7132"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2014.11.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.01.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000062884.69432.A0"},{"key":"e_1_2_8_7_1","first-page":"319","article-title":"Successful aging among african american older adults with type 2 diabetes","volume":"72","author":"Chard S.","year":"2017","journal-title":"Journals of Gerontology Series B\u2010Psychological Sciences and Social Sciences"},{"key":"e_1_2_8_8_1","first-page":"1891","article-title":"Inbibitional effect of Sandy Tea on the carcinoma cells growth and tumor metastasis","volume":"29","author":"Feng X.","year":"2013","journal-title":"Modern Food Science and Technology"},{"key":"e_1_2_8_9_1","first-page":"128","article-title":"The nutrient analysis and evaluation of Sanye Insect\u2010fermented tea","volume":"45","author":"Guo S. 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