{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:26:57Z","timestamp":1765232817865,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["933926"],"award-info":[{"award-number":["933926"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chicken protein hydrolysates (CPHs) generated from rest raw materials through enzymatic hydrolysis\u00a0using Corolase PP or Alcalase were shown to reduce inflammation and stimulate hepatic mitochondrial fatty acid oxidation in high\u2010fat\u2010fed mice. This study investigates the effect of CPH diets in atherosclerosis\u2010prone apolipoprotein E\u2010deficient (Apoe<jats:sup>\u2212\/\u2212<\/jats:sup>) mice. Apoe<jats:sup>\u2212\/\u2212<\/jats:sup> mice were divided into three groups of 12 animals and fed high\u2010fat diets with casein (control), Alcalase CPH, or Corolase PP CPH. After 12\u00a0weeks, mice were sacrificed, blood samples were collected, and aorta was dissected for subsequent <jats:italic>\u00e9n face<\/jats:italic> analysis. Mice fed Corolase PP CPH but not Alcalase CPH had significantly lower % atherosclerotic plaque area in the aortic arch compared to controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.015 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.077, respectively). Plasma and liver cholesterol and triacylglycerol remained constant, but levels of the fatty acid C20:5n\u20103 were increased, accompanied by an elevated delta\u20105 desaturase index in both CPHs groups. Moreover, a significant reduction of plasma MCP\u20101 was detected in Corolase PP CPH compared to control. Overall, our data show that protein hydrolysates from chicken reduced atherosclerosis and attenuated systemic risk factors related to atherosclerotic disorders, not related to changes in the level of plasma cholesterol.<\/jats:p>","DOI":"10.1002\/fsn3.1300","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T03:16:15Z","timestamp":1576293375000},"page":"3052-3060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A chicken protein hydrolysate exerts anti\u2010atherosclerotic effect beyond plasma cholesterol\u2010lowering activity in Apoe<sup>\u2212\/\u2212<\/sup> mice"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9718-5117","authenticated-orcid":false,"given":"Bodil","family":"Bj\u00f8rndal","sequence":"first","affiliation":[{"name":"Department of Clinical Science University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Aloysius","sequence":"additional","affiliation":[{"name":"Department of Clinical Science University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Clinical Science University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasa","family":"Slizyte","sequence":"additional","affiliation":[{"name":"SINTEF Ocean Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavol","family":"Bohov","sequence":"additional","affiliation":[{"name":"Department of Clinical Science University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Karina","family":"Carvajal","sequence":"additional","affiliation":[{"name":"SINTEF Ocean Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf K.","family":"Berge","sequence":"additional","affiliation":[{"name":"Department of Clinical Science University of Bergen Bergen Norway"},{"name":"Department of Heart Disease Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicines6010005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-12-143"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.03.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/o59-099"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf1027944"},{"key":"e_1_2_10_7_1","first-page":"293","article-title":"Quantification of atherosclerosis in mice","volume":"209","author":"Daugherty A.","year":"2003","journal-title":"Methods in Molecular Biology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.11.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508960906"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800605774962077"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-9-r200"},{"issue":"6","key":"e_1_2_10_12_1","first-page":"421","article-title":"Oxidative stress in cardiovascular disease","volume":"46","author":"Lakshmi S. 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