{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:10:48Z","timestamp":1791933048764,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003668","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","award":["115044\u201003\u20102\u2010HD020"],"award-info":[{"award-number":["115044\u201003\u20102\u2010HD020"]}],"id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Social cost of insomnia in modern society is gradually increasing. Due to various social phenomena and lifestyles that take away the opportunity of good quality of sleep, problems of insomnia cannot be easily figured out. Prescription of sleeping pills for insomnia patients can cause other inconveniences due to their side effects beyond their intended purposes. On the other hand,\n                    <jats:italic>Passiflora incarnata L.<\/jats:italic>\n                    (PI) has been widely used in South America for several centuries, showing effectiveness for sleep, sedation, anxiety, and so on in the civilian population. However, reports on the treatment efficacy of this herbal medicinal plant for insomnia patients through standardization as a sleeping agent have been very rare. Therefore, we obtained leaves and fruits of PI (8:2 by weight) as powder to prepare an extract. It was then applied to C6 rat glioma cells to quantitate mRNA expression levels of GABA receptors. Its sleep\u2010inducing effect was investigated using experimental animals. PI extract (6\u00a0\u03bcg\/ml) significantly decreased GABA receptors at 6\u00a0hr after treatment. Immobility time and palpebral closing time were significantly increased after single (500\u00a0mg\/kg) or repeated (250\u00a0mg\/kg) oral administration. In addition, blood melatonin levels were significantly increased in PI extract\u2010treated animals after both single and repeated administrations. These results were confirmed through several repeated experiments. Taken together, these results confirmed that PI extract had significant sleep\u2010inducing effects in cells and animals, suggesting that PI extract might have potential for treating human insomnia.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.1341","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T12:16:48Z","timestamp":1576757808000},"page":"557-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sleep\u2010inducing effect of\n                    <i>Passiflora incarnata L.<\/i>\n                    extract by single and repeated oral administration in rodent animals"],"prefix":"10.1002","volume":"8","author":[{"given":"Gwang\u2010Ho","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biomedical Laboratory Science College of Medical Sciences Soonchunhyang University Asan 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