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Similarly, pain management is a public health concern particularly due to the increase in use of opioid medications, which have a significant side effect profile. Flavonoids can modulate numerous physiological functions including emotional and anti\u2010nociceptive processes. Gold lotion (GL) is a natural product based on the extract of six citrus peels rich in flavonoids (0.45\u00a0mg\/ml) with numerous reported biological activities. In the present study, we investigated the effect of repeated administration of GL in a battery of behavioral tests, including the open field test (OFT), forced swim test (FST), and von Frey test (vFT), in rats. While the OFT measured anxiolytic\u2010related effects, the FST evaluated depression\u2010related behavior. The vFT evaluated mechanical allodynia in two rat models of peripheral inflammation induced by carrageenan or complete Freund's adjuvant (CFA) administration. Treatment with GL reduced mechanical allodynia after either carrageenan or CFA administration. On the other hand, repeated GL administration did not modulate any behavior evaluated by OFT or FST. Consumption of GL inhibits behavioral signs of inflammatory pain. Therefore, GL may be a valuable analgesic product to be used for inflammatory pain.<\/jats:p>","DOI":"10.1002\/fsn3.1566","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T04:03:52Z","timestamp":1590033832000},"page":"3173-3180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Repeated administration of a flavonoid\u2010based formulated extract from citrus peels significantly reduces peripheral inflammation\u2010induced pain in the rat"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4758-0562","authenticated-orcid":false,"given":"Tommaso","family":"Iannitti","sequence":"first","affiliation":[{"name":"Charles River Discovery Research Services UK Limited Portishead UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8122-9170","authenticated-orcid":false,"given":"Alessandro","family":"Di 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