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Here, we analyze the proteomics and metagenomic changes in a LP10 supplemented mouse model. Male ICR mice were divided into two groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) to receive by oral gavage either vehicle or of LP10 for 6\u00a0weeks. Proteins changes by LP10 treatment were subjected to the Ingenuity Pathway Analysis (IPA) to provide corroborative evidence for differential regulation of molecular and cellular functions affecting metabolic processes. Fecal samples were obtained from each mouse, and the microbial community profile analyzed by pyrosequencing of the 16S rRNA genes. Of the 880 identified proteins, 25 proteins were significantly downregulated and 44 proteins were significantly upregulated in the LP10 treated compared to vehicle group. LP10 supplementation shift in the gut microbiota to butyrate\u2010producing members and provided from lipid oxidation since peroxisomal fatty acid oxidation in liver.<\/jats:p>","DOI":"10.1002\/fsn3.1635","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T03:04:36Z","timestamp":1591239876000},"page":"3525-3534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Proteome and microbiota analysis highlight <i>Lactobacillus plantarum<\/i> TWK10 supplementation improves energy metabolism and exercise performance in mice"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-6751","authenticated-orcid":false,"given":"Yi\u2010Ming","family":"Chen","sequence":"first","affiliation":[{"name":"College of physical education Hubei Normal University Huangshi 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Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Chyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for General Education Chang Gung University of Science and Technology Taoyuan Taiwan"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Sleep Center Linkou\u2010Chang Gung Memorial Hospital Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Shuo","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shuang Ho Hospital Taipei Medical University Taipei Taiwan"},{"name":"School of Nutrition and Health Sciences College of Nutrition Taipei Medical University Taipei 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