{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:06:14Z","timestamp":1762956374875,"version":"3.40.5"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012712","name":"Helen Keller Foundation for Research and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012712","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006641","name":"UNICEF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Complementary foods in Africa are often poor sources of bioavailable iron. We assessed the efficacy of iron\u2010fortified wheat\u2010based infant cereal (IC) to reduce the risk of iron deficiency anemia in children aged 18\u201359\u00a0months in Cameroon. A 6\u2010month double\u2010blind, cluster\u2010randomized controlled trial was conducted in 2017 among anemic (hemoglobin 7\u201311\u00a0g\/dl) but otherwise healthy children. In conjunction with usual diet, children received two 50\u00a0g servings\/day of a standard, micronutrient\u2010fortified IC (providing 3.75\u00a0mg iron\/serving; <jats:italic>n<\/jats:italic>\u00a0=\u00a0106) or the same IC without iron fortification (<jats:italic>n<\/jats:italic>\u00a0=\u00a099). Anthropometric measurements, blood sampling, and systematic deworming were performed in all children at baseline (pre\u2010intervention), 3, and 6\u00a0months. Mean hemoglobin, ferritin adjusted for C\u2010reactive protein (CRP), serum iron, transferrin saturation, prevalence of anemia, iron deficiency, and iron deficiency anemia as well as anthropometrics were compared between the groups at baseline, 3, and 6\u00a0months. Compared to the control group, children consuming the iron\u2010fortified IC had significantly higher baseline\u2010adjusted mean hemoglobin (10.0\u00a0\u00b1\u00a01.8 vs. 9.7\u00a0\u00b1\u00a01.4\u00a0g\/dl, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.023), ferritin adjusted for CRP (16.1\u00a0\u00b1\u00a08.3 vs. 9.5\u00a0\u00b1\u00a07.5\u00a0\u03bcg\/L, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), serum iron (14.5\u00a0\u00b1\u00a03.9 vs. 11.2\u00a0\u00b1\u00a04.4\u00a0\u03bcg\/dl; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and transferrin saturation (19.0\u00a0\u00b1\u00a017.4 vs. 10.7\u00a0\u00b1\u00a012.5%; <jats:italic>p<\/jats:italic>\u00a0\u02c2\u00a0.001) at 6\u00a0months. The prevalence of anemia, iron deficiency, and iron deficiency anemia at 6\u00a0months decreased by a larger extent in the iron\u2010fortified group versus controls (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). In addition, at 6\u00a0months, children in the iron\u2010fortified group demonstrated higher weight\u2010for\u2010age <jats:italic>z<\/jats:italic>\u2010scores (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.016) compared to the control group. Wheat\u2010based IC fortified with 7.5\u00a0mg ferrous fumarate administered daily for 6\u00a0months improved iron and nutritional status and decreased the prevalence of iron deficiency anemia in children aged 18\u201359\u00a0months in Salapoumb\u00e9, Cameroon.<\/jats:p>","DOI":"10.1002\/fsn3.1639","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T06:01:33Z","timestamp":1591336893000},"page":"3566-3577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of an iron\u2010fortified infant cereal to reduce the risk of iron deficiency anemia in young children in East Cameroon"],"prefix":"10.1002","volume":"8","author":[{"given":"Tetanye","family":"Ekoe","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ousmaila I.","family":"Bianpambe","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicitee","family":"Nguefack","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Pondi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie M.","family":"Kana\u2010Sop","sequence":"additional","affiliation":[{"name":"Faculty of Sciences University of Douala Douala Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-1600","authenticated-orcid":false,"given":"Nicholas P.","family":"Hays","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 Product Technology Center \u2013 Nutrition Vevey Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Medoua","sequence":"additional","affiliation":[{"name":"Food and Nutrition Research Center Institute for Medical Research and Study of Medicinal Plants Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul N.","family":"Koki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(07)60817\u20104"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102006005000031"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.9.849"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114519003386"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.10.2678"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/mcn.12163"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.12.2534"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/38.10.2078"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.129346"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.2.224"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337674"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.1.86"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046\u20104053\u20102\u201067"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0271\u20105317(02)00487\u20106"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.10.2527"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u201012\u2010506"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.142323"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.245076"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.167775"},{"volume-title":"Human 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