{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:12:01Z","timestamp":1782425521686,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP 24500987"],"award-info":[{"award-number":["JP 24500987"]}]},{"name":"JSPS KAKENHI","award":["JP15K00832"],"award-info":[{"award-number":["JP15K00832"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The protective effects of <jats:italic>Mallotus furetianus<\/jats:italic> extract (MF) on liver fibrosis induced with ethanol were examined using in vivo and in vitro model. MF treatment suppressed plasma alanine aminotransferase and aspartate aminotransferase activities in ethanol plus carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced cirrhosis rat model. MF also suppressed the increase in type l collagen and \u03b1\u2010smooth muscle actin expression in the livers of ethanol plus CCl4\u2010induced rat by the maintenance of intracellular glutathione levels. Furthermore, we evaluated the effect of MF on the alcohol\u2010induced activation of hepatic stellate cells (HSCs), which are responsible for the increased production and deposition of the extracellular matrix in liver injury. Here, we observed the enhancement of the intracellular reactive oxygen species (ROS) levels and the increase in type I collagen and a\u2010SMA expression in HSCs activated with ethanol. However, the enhanced ROS levels were suppressed with the treatments of MF or diphenyleneiodonium (DPI). Furthermore, the treatment of MF or DPI suppressed the increase in type I collagen and a\u2010SMA expression activated with ethanol. We also observed that the treatment of MF or LY194002 suppressed the increase in type I collagen expression in HSCs activated with ethanol, suggesting that ethanol induced type I collagen expression via the PI3K\u2010Akt signaling pathway. On the other hand, the suppression of the synthesis of type I collagen in ethanol and MF\u2010treated HSCs was inhibited by H\u201089. From these results, MF may suppress the increase in the activity of NADPH oxidase in HSCs activated with ethanol through the cAMP\u2010PKA pathway.<\/jats:p>","DOI":"10.1002\/fsn3.1709","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T03:59:00Z","timestamp":1591847940000},"page":"3936-3946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Mallotus furetianus<\/i> extract protects against ethanol\u2010induced liver injury via the activation of the cAMP\u2010PKA pathway"],"prefix":"10.1002","volume":"8","author":[{"given":"Eri","family":"Yoshikawa","sequence":"first","affiliation":[{"name":"Department of Food and Human Health Sciences Graduate School of Human Life Science Osaka City University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Matsui\u2010Yuasa","sequence":"additional","affiliation":[{"name":"Department of Food and Human Health Sciences Graduate School of Human Life Science Osaka City University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy School of Pharmacy Kitasato University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy School of Pharmacy Kitasato University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8167-3693","authenticated-orcid":false,"given":"Akiko","family":"Kojima\u2010Yuasa","sequence":"additional","affiliation":[{"name":"Department of Food and Human Health Sciences Graduate School of Human Life Science Osaka City University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2012.08.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.07.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24465"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2247"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1350664"},{"key":"e_1_2_8_10_1","first-page":"56","article-title":"Extract of traditional pickling melon prevents ethanol\u2010induced liver injury in rats","volume":"6","author":"Kojima\u2010Yuasa A.","year":"2017","journal-title":"International Journal of Food and Nutritional Science"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(03)00087-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(96)06434-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840100417"},{"key":"e_1_2_8_14_1","first-page":"32","article-title":"The biological character and ecological distribution of Mallotus furetianus in Hainan","volume":"10","author":"Lin H.","year":"1992","journal-title":"Natural Science Journal of Hainan University"},{"key":"e_1_2_8_15_1","first-page":"608","article-title":"Effect of Mallotus furetianun on preventive development of atherosclerosis in atherosclerotic rats","volume":"14","author":"Liu Y. 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