{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:05:28Z","timestamp":1747148728425,"version":"3.40.5"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"High level Talents Project of Chongqing University of Education","award":["2013BSRC001"],"award-info":[{"award-number":["2013BSRC001"]}]},{"name":"Scientific Research Foundation for Returned Overseas Chinese Scholars"},{"name":"State Education Ministry","award":["Jiaowaisiliu (2014)1685"],"award-info":[{"award-number":["Jiaowaisiliu (2014)1685"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Insect tea is consumed as a health beverage in China. The insect tea primary leaf (ITPL) is rich in bioactive substances, which are also used as traditional Chinese medicine. This study investigated the role of ITPL in reducing the oxidative response induced by D\u2010galactose in mice. Mice were intraperitoneally injected with D\u2010galactose to induce oxidative damage. The effect of ITPL was tested by pathological observation, serum detection with kits, quantitative polymerase chain reaction, and Western blot. The experimental results show that ITPL increased the thymus, brain, heart, liver, spleen, and kidney indices of oxidized mice. ITPL increased superoxide dismutase, glutathione peroxidase, and glutathione levels and reduced nitric oxide and malondialdehyde levels in the serum, liver, and spleen in oxidative damaged mice. The pathological observations show that ITPL reduced the oxidative damage of the liver and spleen in mice induced with D\u2010galactose. Simultaneously, ITPL upregulated mRNA expression of neuronal nitric oxide synthase, endothelial nitric oxide synthase, cuprozinc\u2010superoxide dismutase, manganese superoxide dismutase, catalase, heme oxygenase\u20101, nuclear factor\u2010erythroid 2 related factor 2, \u03b3\u2010glutamylcysteine synthetase, and NAD(P)H dehydrogenase [quinone] 1, and downregulated the expression of inducible nitric oxide synthase in the liver and spleen of oxidized mice. ITPL had beneficial preventive effects on the oxidative damage caused by D\u2010galactose in mice and was more effective as an antioxidant than vitamin C. The component analysis test by high\u2010performance liquid chromatography indicated that ITPL contained the following seven compounds: neochlorogenic acid, cryptochlorogenic acid, rutin, kaempferin, isochlorogenic acid B, isochlorogenic acid A, and hesperidin. ITPL is a plant with excellent antioxidant activities derived from its bioactive substances.<\/jats:p>","DOI":"10.1002\/fsn3.1821","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T14:09:13Z","timestamp":1597327753000},"page":"5160-5171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Preventive effect of insect tea primary leaf (<i>Malus sieboldii<\/i> (Regal) Rehd.) extract on D\u2010galactose\u2010induced oxidative damage in mice"],"prefix":"10.1002","volume":"8","author":[{"given":"Ruokun","family":"Yi","sequence":"first","affiliation":[{"name":"Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing China"},{"name":"Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing China"},{"name":"Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Intensive Care Unit The First People's Hospital of Chongqing Liang Jiang New Area Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfeng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science and Biotechnology Yangtze Normal University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfei","family":"Mu","sequence":"additional","affiliation":[{"name":"Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing China"},{"name":"Intensive Care Unit The First People's Hospital of Chongqing Liang Jiang New Area Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Public Health Our Lady of Fatima University Valenzuela Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-7865","authenticated-orcid":false,"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing China"},{"name":"Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing China"},{"name":"Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7132"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2014.11.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.01.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000062884.69432.A0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.60.62"},{"key":"e_1_2_6_7_1","first-page":"319","article-title":"Successful aging among african american older adults with type 2 diabetes","volume":"72","author":"Chard S.","year":"2017","journal-title":"Journals of Gerontology: Series B"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.08.057"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100240"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9551"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-018-3247-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22413"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12601"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101068"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.09.023"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5246\/jcps.2014.08.070"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00416.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8090381"},{"key":"e_1_2_6_19_1","first-page":"2529","article-title":"Plant polyphenols: Antioxidant capacity and application in animal production","volume":"25","author":"Li H. 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