{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:58:05Z","timestamp":1791773885141,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the protective effects of celastrol on mice with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), and to explore its underlying mechanism. The levels of low\u2010density lipoprotein cholesterol (LDL\u2010C), high\u2010density lipoprotein cholesterol (HDL\u2010C), total cholesterol (TC), and triglyceride (TG) in serum were tested. Malondialdehyde (MDA) and superoxide dismutase (SOD), GOT, and GPT in serum were also detected. The histopathological changes of liver tissues were observed by HE staining. The apoptosis cell number of liver tissues was measured by TUNEL staining. Nrf\u20102 and HO\u20101 protein and mRNA expression were evaluated by IHC, WB, and RT\u2010PCR assay. Celastrol had effects to depress TG, TC, LDL\u2010C, GPT, GOT, and MDA concentration and increase HDL\u2010C and SOD concentration (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05, respectively) with dose\u2010dependent. Compared with model group, apoptosis cell number was significantly depressed in Cel\u2010treated groups with dose\u2010dependent (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05, respectively). Nrf\u20102 and HO\u20101 mRNA and protein expressions were significantly improved in Cel\u2010treated groups with dose\u2010dependent (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05, respectively). Celastrol can inhibit the oxidative stress reaction and liver cell apoptosis via regulation Nrf2\/HO\u20101 pathway in T2DM mice with NAFLD.<\/jats:p>","DOI":"10.1002\/fsn3.1917","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T06:38:25Z","timestamp":1602571105000},"page":"6207-6216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Protective effect of celastrol on type 2 diabetes mellitus with nonalcoholic fatty liver disease in mice"],"prefix":"10.1002","volume":"8","author":[{"given":"JuanJuan","family":"Sun","sequence":"first","affiliation":[{"name":"The Second District of Hepatopathy Qingdao No. 6 People's Hospital  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010juan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second District of Hepatopathy Qingdao No. 6 People's Hospital  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[{"name":"The Second District of Hepatopathy Qingdao No. 6 People's Hospital  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TingTing","family":"Li","sequence":"additional","affiliation":[{"name":"The Second District of Hepatopathy Qingdao No. 6 People's Hospital  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6610-1750","authenticated-orcid":false,"given":"YiDi","family":"Han","sequence":"additional","affiliation":[{"name":"The Second District of Hepatopathy Qingdao No. 6 People's Hospital  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.04.025"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.biopha.2017.07.021","article-title":"Improvement of mitochondrial function by celastrol in palmitate\u2010treated C2C12 myotubes via activation of PI3K\u2010Akt signaling pathway","volume":"93","author":"Bakar M. 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