{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:27:46Z","timestamp":1789961266513,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience and Biotechnology","doi-asserted-by":"publisher","award":["KGS1002012"],"award-info":[{"award-number":["KGS1002012"]}],"id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A2C2087608"],"award-info":[{"award-number":["2019R1A2C2087608"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In Asia, <jats:italic>Vigna angularis<\/jats:italic> (azuki bean) has been used as a traditional medicine to treat various diseases because of its biological properties. Osteoarthritis (OA) and osteoporosis (OP) are common regenerative bone diseases that are characterized by deterioration of joint and bone structure. In this study, we evaluated the effects of <jats:italic>Vigna angularis<\/jats:italic> extract (VAE) on monosodium iodoacetate (MIA)\u2010induced OA and ovariectomy (OVX)\u2010induced OP models. In the MIA\u2010induced OA results, severe OA was alleviated by the administration of VAE. Extensive local damage in the cartilage and hemorrhagic and edematous of surrounding tissues were decreased by VAE treatment. Articular cartilage was almost intact except for a focal mild abrasion, and the surface was glistening, similar to that of the normal joint. In the OVX\u2010induced OP results, bone mineral content (BMC) and bone mineral density (BMD) were recovered by VAE treatment, and it improved the microstructures of bone. These results show that VAE could inhibit OA and OP symptoms.<\/jats:p>","DOI":"10.1002\/fsn3.1944","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T14:50:45Z","timestamp":1603205445000},"page":"6550-6556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Beneficial effects of <i>Vigna angularis<\/i> extract in osteoporosis and osteoarthritis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-6766","authenticated-orcid":false,"given":"Hyung Jin","family":"Lim","sequence":"first","affiliation":[{"name":"Immunoregulatory Material Research Center Korea Research Institute of Bioscience and Biotechnology  Jeongeup\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Ik","family":"Park","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Chonnam National University  Gwangju\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Gyeong","family":"Bak","sequence":"additional","affiliation":[{"name":"Immunoregulatory Material Research Center Korea Research Institute of Bioscience and Biotechnology  Jeongeup\u2010si Korea"},{"name":"Department of Marine Bio Food Science Chonnam National University  Yeosu\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Hee","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Marine Bio Food Science Chonnam National University  Yeosu\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Immunoregulatory Material Research Center Korea Research Institute of Bioscience and Biotechnology  Jeongeup\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Bin","family":"Baek","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Chonnam National University  Gwangju\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Min","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Chonnam National University  Gwangju\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Chonbuk National University  Jeonju\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Woong","family":"Lee","sequence":"additional","affiliation":[{"name":"Immunoregulatory Material Research Center Korea Research Institute of Bioscience and Biotechnology  Jeongeup\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-7666","authenticated-orcid":false,"given":"Seung\u2010Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Immunoregulatory Material Research Center Korea Research Institute of Bioscience and Biotechnology  Jeongeup\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mun\u2010Chual","family":"Rho","sequence":"additional","affiliation":[{"name":"Immunoregulatory Material Research Center Korea Research Institute of Bioscience and Biotechnology  Jeongeup\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2313-x"},{"issue":"4","key":"e_1_2_6_3_1","first-page":"391","article-title":"The role of cytokines in postmenopausal osteoporosis","volume":"66","author":"Brincat S. 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