{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:52:13Z","timestamp":1791928333493,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Okra (<jats:italic>Abelmoschus esculentus)<\/jats:italic>\u00a0has various bioactive components used for the treatment of different diseases such as gastritis and ulcers. This research aims to examine the anti\u2010inflammatory and anti\u2010ulcer attributes of okra extract against gastric lesions. Adult Sprague Dawley male albino rats were divided into five groups. The negative control (G1) received normal feed, positive control (G2) received ulcer\u2010inducing drug aspirin 150\u00a0mg\/kg of body weight (b.w), G3 group received reference drug omeprazole 20\u00a0mg\/kg of b.w, G4 group received okra extract 250\u00a0mg\/kg of b.w, and G5 group received 500\u00a0mg\/kg of b.w. Acute gastric damage was induced in G1, G2, G3, and G4 using aspirin 150\u00a0mg\/kg of b.w, during 14\u2010day\u2010long efficacy trials after that all the animals were sacrificed. Anti\u2010ulcer parameters and histopathological analysis of stomachs were performed to evaluate the degree of recovery against tissue damage by the administration of okra extract. The obtained results indicated that the 500\u00a0mg\/kg of b.w okra extract exerted a protective effect in aspirin\u2010induced gastric ulcers by significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) reducing ulcer score, ulcer area, total acidity, and gastric volume, and significantly (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.05) increasing gastric pH. Moreover, histopathological observation revealed that gastric mucosa was normal in G1, G3, G4, and G5; however, disruptions in the gastric epithelium were observed in G2. Congestion was observed in all groups except G1 and G5. Gastric pits and gastric glands were increased in size in G2 and G4. A higher concentration of okra extract (500\u00a0mg\/kg of b.w) showed almost similar results when compared to the reference drug omeprazole.<\/jats:p>","DOI":"10.1002\/fsn3.1963","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T15:17:05Z","timestamp":1603466225000},"page":"6691-6698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ethanolic extract of okra has a potential gastroprotective effect on acute gastric lesions in Sprague Dawley rats"],"prefix":"10.1002","volume":"8","author":[{"given":"Hafsa","family":"Yasin","sequence":"first","affiliation":[{"name":"National Institute of Food Science and Technology Faculty of Food Nutrition and Home Sciences University of Agriculture Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farwa","family":"Tariq","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology Faculty of Food Nutrition and Home Sciences University of Agriculture Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysha","family":"Sameen","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology Faculty of Food Nutrition and Home Sciences University of Agriculture Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazir","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Institute of Home and Food Sciences Faculty of Life Sciences Government College University Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-0277","authenticated-orcid":false,"given":"Muhammad Faisal","family":"Manzoor","sequence":"additional","affiliation":[{"name":"Institute of Home and Food Sciences Faculty of Life Sciences Government College University Faisalabad Pakistan"},{"name":"School of Food Science and Engineering South China University and Technology Guangzhou China"},{"name":"School of Food and Biological Engineering Jiangsu University Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yasin","sequence":"additional","affiliation":[{"name":"District Head Quarters Hospital Pakpattan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyaba","family":"Tariq","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology Faculty of Food Nutrition and Home Sciences University of Agriculture Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Waheed","family":"Iqbal","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering Jiangsu University Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Ishfaq","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology Faculty of Food Nutrition and Home Sciences University of Agriculture Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Mahmood","sequence":"additional","affiliation":[{"name":"National Institute of Food Science and Technology Faculty of Food Nutrition and Home Sciences University of Agriculture Faisalabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-1962","authenticated-orcid":false,"given":"Azhari","family":"Siddeeg","sequence":"additional","affiliation":[{"name":"Department of Food Engineering and Technology Faculty of Engineering and Technology University Gezira Wad Medani Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"2159","article-title":"Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: In vivo animal study","volume":"9","author":"Abourehab M. 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