{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:08:13Z","timestamp":1787238493965,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Antidiabetic properties of red yeast rice, bitter gourd, and chromium have gained scientific support. This study aimed to test whether a nutraceutical combination of these 3 materials prevented dedifferentiation of pancreatic \u03b2 cells. Male db\/db mice (8\u00a0weeks of age) were allocated into four groups (DB, DB\/L, DB\/M, and DB\/H;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a08\u201310) and fed a high\u2010fat diet containing 0%, 0.2%, 0.4%, or 1% nutraceutical, respectively, whereas wild\u2010type mice receiving a standard diet served as a healthy control (C;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010). The nutraceutical contained 10\u00a0mg\/g monacolin K, 165\u00a0\u00b5g\/g chromium, and 300\u00a0mg\/g bitter gourd. After 8\u2010weeks dietary treatment, diabetic syndromes (including hyperglycemia, hyperphagia, excessive drinking, polyuria, glucosuria, albuminuria, and glucose intolerance), were improved by the nutraceutical in a dose\u2010dependent fashion. Decreased insulin and increased glucagon in serum and pancreatic islets in db\/db mice were abolished in the DB\/H group. Furthermore, supplementation curtailed dedifferentiation of \u03b2 cells, as evidenced by decreasing the dedifferentiation marker (\n                    <jats:italic>Aldh1a3<\/jats:italic>\n                    ) and increasing \u03b2\u2010cell\u2010enriched genes and transcription factors (\n                    <jats:italic>Ins1<\/jats:italic>\n                    ,\n                    <jats:italic>Ins2<\/jats:italic>\n                    , FOXO1, and NKX6.1), as well as nuclear localization of NKX6.1 in pancreatic islets when compared to the DB group. We concluded that this nutraceutical, a combination of\n                    <jats:italic>Monascus purpureus<\/jats:italic>\n                    ,\n                    <jats:italic>Momordica charantia<\/jats:italic>\n                    , and chromium, could be used as an adjunct for type 2 diabetes treatment and delay disease progression by sustaining \u03b2\u2010cell function.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.1966","type":"journal-article","created":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T11:54:29Z","timestamp":1603626869000},"page":"6718-6726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["An antidiabetic nutraceutical combination of red yeast rice (\n                    <i>Monascus purpureus<\/i>\n                    ), bitter gourd (\n                    <i>Momordica charantia<\/i>\n                    ), and chromium alleviates dedifferentiation of pancreatic \u03b2 cells in db\/db mice"],"prefix":"10.1002","volume":"8","author":[{"given":"Ke\u2010Ying","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Nutrition China Medical University Taichung Taiwan"},{"name":"Lishui Municipal Central Hospital Lishui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu\u2010Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nutrition China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Shun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nutrition China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4846-3245","authenticated-orcid":false,"given":"Pei\u2010Min","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Nutrition China Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,25]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"13","article-title":"Effects of Momordica charantia on pancreatic histopathological changes associated with streptozotocin\u2010induced diabetes in neonatal rats","volume":"26","author":"Abdollahi M.","year":"2011","journal-title":"Histology and Histopathology"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(98)00022-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/496169"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0792"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0304"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-925116"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.05.024"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.12.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2860"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0026"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0266"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0610-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1425"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3fo60268k"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1213"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122555"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-018-9523-x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2222-1808(13)60052-3"},{"issue":"9","key":"e_1_2_10_20_1","first-page":"4047","article-title":"The importance of \u03b2\u2010cell failure in the development and progression of type 2 diabetes","volume":"86","author":"Kahn S. 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