{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:36:13Z","timestamp":1785796573850,"version":"3.56.0"},"reference-count":83,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin D deficiency is a major public health concern of pregnant women and neonates worldwide, affecting more than half of neonates. Studies report inconsistent and inconclusive effects of vitamin D treatment on neonatal sepsis. This study aimed to provide conclusive evidence regarding the effect of maternal and cord blood vitamin D levels on neonatal sepsis. Data were retrieved from the electronic database (Web of Science, Scopus, CINAHL [EBSCOhost], ProQuest, EMBASE [Ovid], PubMed, Emcare, MEDLINE [Ovid], and gray literature sources [World cat, Mednar, Google scholar and Google]). Joanna Briggs Institute quality assessment tool was utilized for quality assessment while analysis was performed using Open Meta\u2010analyst, Comprehensive Meta\u2010analysis version 3.3.070, and Review Manager version 5.3 software. From the 18 studies included in the study, the overall prevalence of vitamin D deficiency among neonates was 61% (95% CI: 44.3, 77.7); 79.4% (95% CI: 71.6, 87.3) of neonates with sepsis were vitamin D deficient as were 43.7% (23.4, 63.9) of sepsis\u2010free neonates. Neonates born from mothers with low vitamin D levels were at greater risk of developing neonatal sepsis with a weighed mean difference of \u22128.57\u00a0ng\/ml (95% CI: \u221213.09, \u22124.05). Similarly, neonates with low cord vitamin D levels were at risk for neonatal sepsis with a mean difference of \u22128.78\u00a0ng\/ml (95% CI:\u201011.58, \u22125.99). The incidence of EONS in full\u2010term newborns was significantly associated with low maternal and cord blood vitamin D levels with weighed mean differences of \u221211.55ng\/ml (95% CI: \u221217.63, \u22125.46) &amp; \u221211.59\u00a0ng\/ml (95% CI:\u201016.65, \u22126.53), respectively. Low levels of vitamin D both in the cord blood and maternal blood were significantly associated with neonatal sepsis. Hence, vitamin D supplementation for pregnant women and newborns could decrease neonatal sepsis.<\/jats:p>","DOI":"10.1002\/fsn3.2003","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T22:21:57Z","timestamp":1605046917000},"page":"375-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of vitamin D on neonatal sepsis: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-3896","authenticated-orcid":false,"given":"Zebenay","family":"Workneh Bitew","sequence":"first","affiliation":[{"name":"St. Paul\u2019s Hospital Millennium Medical College  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teshager","family":"Worku","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery College of Health and Medical Sciences Haramaya University  Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayinalem","family":"Alemu","sequence":"additional","affiliation":[{"name":"Ethipian Public Health Institute  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v8n9p83"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9369051"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmz021"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1179\/2046905514y.0000000148"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02519"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"124","article-title":"Serum vitamin D levels in term neonates with early onset sepsis","volume":"3","author":"Aye A.","year":"2018","journal-title":"Pediatr Neonat Biol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03188-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-1949-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3054"},{"issue":"10","key":"e_1_2_11_11_1","first-page":"1","article-title":"Interrater reliability in systematic review methodology: Exploring variation in coder decision\u2010making","volume":"20","author":"Belur J.","year":"2018","journal-title":"Sociological Methods & Research"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.0302"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja15.00798"},{"key":"e_1_2_11_14_1","volume-title":"Reproductive maternal newborn and child health. 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