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This study aimed to explore the effects of nicotinamide riboside (NR) on lipid metabolism and gut microflora\u2010bile acid axis in alcohol\u2010exposed mice. NR significantly improved liver histopathological damage and abnormal liver function. NR as a provider of nicotinamide adenine dinucleotide (NAD+) increased the NAD+\/NADH ratio. Meanwhile, NR inhibited the activation of the protein phosphatase 1 signaling pathway, decreased the liver triglyceride and total bile acid levels, and reduced lipid accumulation. According to the results of gut microflora species analysis, NR intervention changed the microbial community structure at the phylum, family and genus levels, and the species abundances returned to a level similar to these of the normal control group. Besides, the results of high\u2010performance liquid chromatograph\u2010mass spectrometry showed that NR intervention resulted in fecal bile acid levels tending to be normal with decreased chenodeoxycholic acid level and increased deoxycholic acid and hyocholic acid levels. Spearman's correlation analysis showed a correlation between gut microflora and bile acids. Therefore, NR supplementation has the potential to prevent ALD, and its mechanism may be related to regulating lipid metabolism disorders and the gut microflora\u2010bile acid axis.<\/jats:p>","DOI":"10.1002\/fsn3.2007","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T13:10:30Z","timestamp":1608642630000},"page":"429-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of nicotinamide riboside on lipid metabolism and gut microflora\u2010bile acid axis in alcohol\u2010exposed mice"],"prefix":"10.1002","volume":"9","author":[{"given":"Xiao","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Human Nutrition College of Public Health Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilan","family":"Xue","sequence":"additional","affiliation":[{"name":"Basic Medical College Qingdao University of Medicine 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