{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:16:04Z","timestamp":1791839764271,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Walnut oil (WO) is widely used in traditional medicine, and it has become a dietary supplement in many countries. We isolated walnut oil from <jats:italic>Juglans sigillata<\/jats:italic> and evaluated its protective effects on acute intestinal injury, and Toll\u2010like receptor 4 (TLR4)\/nuclear factor\u2010\u03baB (NF\u2010\u03baB) signaling pathway in lipopolysaccharide (LPS)\u2010induced mice was studied. The results showed that the LPS\u00a0+\u00a0WO group significantly decreased serum tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), and IL\u20101\u03b2 levels and increased the jejunum superoxide dismutase (SOD) and glutathione peroxidase (GSH\u2010Px) levels compared with the LPS group. Walnut oil ameliorated the pathological morphology of the LPS\u2010induced acute jejunum injury and decreased jejunum cells apoptosis rate and TLR4\/NF\u2010\u03baB protein expression. Furthermore, the expression of the TLR4\/NF\u2010\u03baB pathway key gene mRNA significantly reduced after treatment with walnut oil. This study concludes that walnut oil can exert the protective effect on LPS\u2010induced acute intestinal injury in mice by inhibiting the TLR4\/NF\u2010\u03baB signaling pathway.<\/jats:p>","DOI":"10.1002\/fsn3.2035","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T08:39:50Z","timestamp":1606552790000},"page":"711-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The protective effect of walnut oil on lipopolysaccharide\u2013induced acute intestinal injury in mice"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-3310","authenticated-orcid":false,"given":"Fujun","family":"Miao","sequence":"first","affiliation":[{"name":"College of Food Science and Technology Yunnan Agricultural University  Kunming China"},{"name":"Yunnan Academy of Forestry and Grassland  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlan","family":"Shan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Yunnan Agricultural University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Aftab Hussain","family":"Shah","sequence":"additional","affiliation":[{"name":"Pakistan Scientific &amp; Technological Information Center Quaid\u2010i\u2010Azam University Campus  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana Waseem","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences Muhammad Nawaz Shareef University of Agriculture  Multan Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxiang","family":"Geng","sequence":"additional","affiliation":[{"name":"Yunnan Academy of Forestry and Grassland  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delu","family":"Ning","sequence":"additional","affiliation":[{"name":"Yunnan Academy of Forestry and Grassland  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanjun","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Yunnan Agricultural University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001236"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4236\/as.2010.12009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10020244"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311717"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02911033"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12732"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/BJN20061866"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2012.760516"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-267x.2018.09.031"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.09.011"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.88"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2016.54"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-267x.2014.11.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.01.006"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0088-4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.04.010"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860719902300503"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2002-1-209"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2fo10152a"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1006-267x.2020.05.014"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02911031"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v62.1371"}],"container-title":["Food Science &amp; 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