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The mice immunodeficiency model was established by CTX. KGM was used to modulate the activities of immunosuppressive mice. It was proved that KGM could promote the proliferation of lymphocyte, thymus, and spleen indices, and alleviate the atrophy of immune organs and weight loss. Besides, in mice serum, the levels of cytokines including TNF\u2010\u03b1, IgG, IL\u20102, and the contents of hemolysin were also increased after treatment with KGM. Furtherly, in nonspecific immunity, KGM could enhance natural killer (NK) cell lethality and pinocytic activity of mouse peritoneal macrophages. Therefore, all of these results revealed that KGM could improve the reduced immunity of CTX\u2010induced mice via modulation innate immunity and adaptive immunity.<\/jats:p>","DOI":"10.1002\/fsn3.2038","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T13:06:27Z","timestamp":1607087187000},"page":"728-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Konjac Glucomannan from <i>Amorphophallus konjac<\/i> enhances immunocompetence of the cyclophosphamide\u2010induced immunosuppressed mice"],"prefix":"10.1002","volume":"9","author":[{"given":"Jiajia","family":"Dai","sequence":"first","affiliation":[{"name":"School of Public Health Wannan Medical College Wuhu China"},{"name":"Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Provincial Engineering Laboratory for Screening and Re\u2010evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Anhui Province Key Laboratory of Active Biological Macromolecules Wuhu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health Wannan Medical College Wuhu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Tea &amp; 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