{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:36:18Z","timestamp":1772127378628,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Puerariae Lobatae Radix (PLR)<\/jats:italic> is the dried root of the leguminous plant <jats:italic>Pueraria lobata<\/jats:italic> and is a common component of health products and medicines. Although it is considered safe, some studies have reported that <jats:italic>PLR<\/jats:italic> has hepatotoxicity and estrogen\u2010like effects. In this study, the safety of high doses of <jats:italic>PLR<\/jats:italic> water extract administered to adolescent <jats:italic>SD<\/jats:italic> rats for 30\u00a0days was evaluated by biochemical, histopathological, and metabolomic analyses. Overall, there were no significant differences between the low\u2010dose and blank control groups in parameter values, including organ wet weight, organ coefficient, routine blood indicators, serum biochemical indexes of liver and renal function, levels of estradiol and testosterone, histopathological parameters, and primary differential metabolite profiles. Compared with the blank control group, the high\u2010dose group may have a certain effect on the liver. These effects might be mediated by abnormal phenylalanine, tyrosine, and tryptophan biosynthesis or phenylalanine metabolism. However, histopathological analyses did not show differences in the liver, kidney, breast, uterus, ovary, testis, and epididymis between the control group and the group treated with a high dose of <jats:italic>PLR<\/jats:italic> water extract. <jats:italic>PLR<\/jats:italic> water extract did not significantly promote the precocity of male and female sexual organs. Overall, <jats:italic>PLR<\/jats:italic> water extract is relatively safe for adolescent <jats:italic>SD<\/jats:italic> rats.<\/jats:p>","DOI":"10.1002\/fsn3.2044","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T11:30:23Z","timestamp":1606822223000},"page":"794-810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safety of high\u2010dose <i>Puerariae Lobatae Radix<\/i> in adolescent rats based on metabolomics"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-5606","authenticated-orcid":false,"given":"Limei","family":"Chen","sequence":"first","affiliation":[{"name":"Jiangxi University of Traditional Chinese Medicine Nanchang 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