{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:42:03Z","timestamp":1790185323721,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:00:00Z","timestamp":1607817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002507","name":"Kangwon National University","doi-asserted-by":"publisher","award":["277520160292"],"award-info":[{"award-number":["277520160292"]}],"id":[{"id":"10.13039\/501100002507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An antibacterial effect of fermented\u2010<jats:italic>Rhus verniciflua<\/jats:italic> extract (FRVE), an urushiol\u2010free extract fermented by <jats:italic>Fomitella fraxinea<\/jats:italic>, on <jats:italic>Helicobacter pylori<\/jats:italic> was evaluated in mice. Minimal inhibitory concentration of FRVE against <jats:italic>H. pylori<\/jats:italic> eradication was checked with serial dilution method in vitro. <jats:italic>H. pylori<\/jats:italic> infection\u2010induced mice were utilized to determine the effect of oral administration of FRVE with\/without standard triple therapy (STT: metronidazole, omeprazole, and clarithromycin) on <jats:italic>H. pylori<\/jats:italic> colonization and gastric inflammation. <jats:italic>H. pylori<\/jats:italic> was clearly eradicated by FRVE at a concentration of \u22652\u00a0mg\/ml in vitro. In animal study, FRVE at a concentration of \u22656\u00a0mg\/ml significantly reduced colonized <jats:italic>H. pylori<\/jats:italic> grading (0.2 vs. 2.2, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) and improved gastric inflammation (0.4 vs. 1.6, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) compared to control. STT with FRVE (3\u00a0mg\/ml) exerted synergistic effect on both <jats:italic>H. pylori<\/jats:italic> colonization grade (STT, 0.6\u00a0\u00b1\u00a00.9; FRVE, 1.4\u00a0\u00b1\u00a00.5; STT\u00a0+\u00a0FRVE, 0.8\u00a0\u00b1\u00a00.4) and gastric inflammation (STT, 0.4\u00a0\u00b1\u00a00.5; FRVE, 1.4\u00a0\u00b1\u00a00.5; STT\u00a0+\u00a0FRVE,1.0\u00a0\u00b1\u00a00.1) compared with single therapy (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). <jats:italic>H. pylori<\/jats:italic> eradication rate of FRVE (6\u00a0mg\/ml) was higher than that of STT (60% vs. 20%). FRVE has potential antibacterial activity against <jats:italic>H. pylori<\/jats:italic> infection and can be used as an additional therapy on STT.<\/jats:p>","DOI":"10.1002\/fsn3.2055","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T11:29:03Z","timestamp":1607858943000},"page":"900-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fermented\u2010<i>Rhus verniciflua<\/i> extract ameliorate <i>Helicobacter pylori<\/i> eradication rate and gastritis"],"prefix":"10.1002","volume":"9","author":[{"given":"Seungwoo","family":"Kim","sequence":"first","affiliation":[{"name":"Institute for Liver and Digestive Diseases Hallym University College of Medicine Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Pyo","family":"Shin","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases Hallym University College of 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Agriculture and Life Sciences Kangwon National University Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hak","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology Hallym University College of Medicine Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-9245","authenticated-orcid":false,"given":"Ki Tae","family":"Suk","sequence":"additional","affiliation":[{"name":"Institute for Liver and Digestive Diseases Hallym University College of Medicine Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,13]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","first-page":"11","article-title":"Molecular mechanisms underlying gallic acid effects against cardiovascular diseases: An update review","volume":"10","author":"Akbari G.","year":"2020","journal-title":"Avicenna 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