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Fifty\u2010five patients suffering from lactose intolerance were randomly divided into control group of 28 lactose intolerance patients who received nonprobiotic yogurt (100\u00a0ml) and experimental group consisted of 27 lactose intolerance patients who received probiotic yogurt fortified (100\u00a0ml) with <jats:italic>L. acidophilus<\/jats:italic> and <jats:italic>Bifidobacterium sp<\/jats:italic>. Each individual received yogurt for one week. Lactose intolerance was confirmed when the patients received 75\u00a0g lactose and were positive after 30\u00a0min until 3\u00a0hr for lactose intolerance symptoms and by hydrogen breath test (HBT). After intervention, the hydrogen level was lower in experimental group in comparison with the control group. Lactose intolerance symptoms in experimental group were much less than the control group. Our findings revealed that probiotic yogurt fortified with <jats:italic>L. acidophilus<\/jats:italic> and <jats:italic>Bifidobacterium sp<\/jats:italic>. could safely and effectively decrease lactose intolerance symptoms and HBT, so our probiotic can be recommended as a treatment of choice in lactose intolerance patients.<\/jats:p>","DOI":"10.1002\/fsn3.2145","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T14:46:53Z","timestamp":1611154013000},"page":"1704-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["The effect of yogurt fortified with <i>Lactobacillus acidophilus<\/i> and <i>Bifidobacterium sp<\/i>. probiotic in patients with lactose intolerance"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6712-6802","authenticated-orcid":false,"given":"Seyed Jalil","family":"Masoumi","sequence":"first","affiliation":[{"name":"Nutrition Research Center School of Nutrition and Food Sciences Shiraz University of Medical Science Shiraz Iran"},{"name":"Gastroenterohepatology Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davood","family":"Mehrabani","sequence":"additional","affiliation":[{"name":"Stem Cell Technology Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Burn and Wound Healing Research Center Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Comparative and Experimental Medicine Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Saberifiroozi","sequence":"additional","affiliation":[{"name":"Digestive Disease Research Center Digestive Disease Research Institute Tehran University of Medical Science Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Fattahi","sequence":"additional","affiliation":[{"name":"Gastroenterohepatology Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Moradi","sequence":"additional","affiliation":[{"name":"Office of Vice President for Health Affairs Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Najafi","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533612440289"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-018-03694-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409091742"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.02963.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO01019A"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001456"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0443-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(99)75479-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-1-19"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods8030092"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.06.012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.2.421s"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1684\/abc.2016.1210"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7095380"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i10.3072"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-40.11.760"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-018-9507-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182549092"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.53201"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152811795564064"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(83)81887-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2016.11.010"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051487"},{"issue":"7","key":"e_1_2_6_25_1","first-page":"613","article-title":"Do probiotics reduce adult lactose intolerance? 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