{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:31:45Z","timestamp":1787725905561,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Acanthopanax trifoliatus<\/jats:italic> (L.) Merr (AT) is a medicinal and edible plant with high nutritional value. The biological activity of <jats:italic>A.\u00a0trifoliatus<\/jats:italic> (L.) Merr and its basis for injury treatment are explored in this paper. AT was ethanol\u2010extracted then refined separately with petroleum ether, chloroform, ethyl acetate, and n\u2010butanol. Active ingredients were analyzed, and anti\u2010bacterial, anti\u2010inflammatory, analgesic, and hemostatic effects were explored. Petroleum ether layer (PEL) extract produced the strongest antibacterial effect. Ethyl acetate layer (EAL) extract had the highest active substance content, with strong hemostatic and analgesic activities. Chloroform layer (CL) extract had the strongest anti\u2010inflammatory effect and significantly reduced IL\u20101\u03b2 protein expression. Active ingredients were analyzed using HPLC and UPLC\u2010MS to determine saponin, polyphenol, flavonoid, and characteristic ingredient contents. EAL extract had the highest polyphenol and flavonoid levels, including rutin, chlorogenic acid, isochlorogenic acid A, and isochlorogenic acid C, which may contribute to its nutritional activities. The study provides a reliable theoretical and practical basis for the applications of AT nutraceutical products.<\/jats:p>","DOI":"10.1002\/fsn3.2190","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T03:55:33Z","timestamp":1614570933000},"page":"2191-2202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Antibacterial, anti\u2010inflammatory, analgesic, and hemostatic activities of <i>Acanthopanax trifoliatus<\/i> (L.) merr"],"prefix":"10.1002","volume":"9","author":[{"given":"Zefeng","family":"Chen","sequence":"first","affiliation":[{"name":"Allan H. Conney Laboratory for Anticancer Research School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shupeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Allan H. Conney Laboratory for Anticancer Research School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiong","family":"Lin","sequence":"additional","affiliation":[{"name":"Allan H. Conney Laboratory for Anticancer Research School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Wu","sequence":"additional","affiliation":[{"name":"Allan H. Conney Laboratory for Anticancer Research School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyi","family":"Liang","sequence":"additional","affiliation":[{"name":"Allan H. Conney Laboratory for Anticancer Research School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xicai","family":"Chen","sequence":"additional","affiliation":[{"name":"Allan H. Conney Laboratory for Anticancer Research School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Allan H. Conney Laboratory for Anticancer Research School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"},{"name":"Susan Lehman Cullman Laboratory for Cancer Research Department of Chemical Biology Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey Piscataway NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7928-2677","authenticated-orcid":false,"given":"Yan","family":"He","sequence":"additional","affiliation":[{"name":"Allan H. Conney Laboratory for Anticancer Research School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Allan H. Conney Laboratory for Anticancer Research School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"},{"name":"School of Biotechnology and Health Sciences Wuyi University Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.574"},{"key":"e_1_2_8_3_1","first-page":"36","article-title":"Research of total flavonoid content and antibacterial activity of the extracts of Acanthopanax trifoliatus (L.)Merr leaves","volume":"38","author":"Cheng S. P.","year":"2017","journal-title":"Food Research & Development"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2015.07.007"},{"issue":"05","key":"e_1_2_8_5_1","first-page":"5","article-title":"Advances in research of Acanthopanax trifoliatus (L)","volume":"9","author":"Gao L.","year":"2018","journal-title":"Merr. 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