{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:46:23Z","timestamp":1779921983654,"version":"3.53.1"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Ficus<\/jats:italic> species have been used as a typical component in food and folk medicine in Asia for centuries. However, little is known regarding the bioactivity and genotoxicity of the recently identified <jats:italic>Ficus dubia<\/jats:italic> (FD), an indigenous plant of the tropical evergreen rain forest. FD is unique from other <jats:italic>Ficus<\/jats:italic> species because of its highly sought\u2010after red\u2010brown latex. Antioxidant properties together with phenolic and flavonoid contents of FD were elucidated. Health\u2010promoting characteristics were examined by studying the inhibition of enzymes as a drug target for diabetes, hypertension, Alzheimer's disease, and obesity, together with anticancer ability against human colorectal adenocarcinoma, human hepatocellular carcinoma, human ovarian carcinoma, human prostate adenocarcinoma, and human lung carcinoma. Besides, FD genotoxicity was tested using the <jats:italic>Drosophila<\/jats:italic> wing spot test. Results showed that both FD root and latex exhibited antioxidant activity due to the presence of phenolics and flavonoids, specifically caffeic acid and cyanidin. The ethanolic fraction of FD root demonstrated a potent antidiabetic mechanism underlying \u03b1\u2010glucosidase inhibitory activity similar to acarbose. This fraction also suppressed lung and ovarian cancer growth, possibly by G1 and G2\/M arrest, respectively. All tested fractions lacked mutagenicity in vivo. Results indicated that FD can be developed as novel antidiabetic compounds; however, its bioactive compounds should be further identified.<\/jats:p>","DOI":"10.1002\/fsn3.2205","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T10:18:20Z","timestamp":1614766700000},"page":"2269-2279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Health\u2010promoting bioactivity and in vivo genotoxicity evaluation of a hemiepiphyte fig, <i>Ficus dubia<\/i>"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-6329","authenticated-orcid":false,"given":"Uthaiwan","family":"Suttisansanee","sequence":"first","affiliation":[{"name":"Institute of Nutrition Mahidol University Salaya, Phuttamonthon Nakhon Pathom Thailand"},{"name":"Food and Nutrition Academic and Research Cluster Institute of Nutrition Mahidol University Salaya, Phuttamonthon Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-386X","authenticated-orcid":false,"given":"Pornsiri","family":"Pitchakarn","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Chiang Mai University Meung Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pisamai","family":"Ting","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Mahidol University Salaya, Phuttamonthon Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woorawee","family":"Inthachat","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Mahidol University Salaya, Phuttamonthon Nakhon Pathom Thailand"},{"name":"Food and Nutrition Academic and Research Cluster Institute of Nutrition Mahidol University Salaya, Phuttamonthon Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parunya","family":"Thiyajai","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Mahidol University Salaya, Phuttamonthon Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daraphan","family":"Rodthayoy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Chiang Mai University Meung Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1629-2808","authenticated-orcid":false,"given":"Jirarat","family":"Karinchai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Chiang Mai University Meung Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhanumas","family":"Chantarasuwan","sequence":"additional","affiliation":[{"name":"Thailand Natural History Museum National Science Museum Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8861-3009","authenticated-orcid":false,"given":"Onanong","family":"Nuchuchua","sequence":"additional","affiliation":[{"name":"National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA) Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7590-7024","authenticated-orcid":false,"given":"Piya","family":"Temviriyanukul","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Mahidol University Salaya, Phuttamonthon Nakhon Pathom Thailand"},{"name":"Food and Nutrition Academic and Research Cluster Institute of Nutrition Mahidol University Salaya, Phuttamonthon Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2011.20.7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200600592301"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14035608"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.02.038"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1066062"},{"key":"e_1_2_8_8_1","first-page":"25","article-title":"Five species of Ficus (Moraceae) new for Thailand","volume":"34","author":"Chantarasuwan B.","year":"2006","journal-title":"Thai Forest Bulletin (Botany)"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2015.02.107"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.04.033"},{"issue":"4","key":"e_1_2_8_11_1","first-page":"417","article-title":"A colorimetric microplate assay method for high throughput analysis of lipase activity","volume":"36","author":"Choi S. 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