{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:17:58Z","timestamp":1790903878322,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Curcumin, a natural polyphenolic compound, is proposed as a potential treatment option for patients with coronavirus disease by inhibiting the entry of virus to the cell, encapsulation of the virus and viral protease, as well as modulating various cellular signaling pathways. In this study, the efficacy and safety of nanocurcumin oral formulation has been evaluated in patients with mild\u2010moderate Coronavirus disease 2019 (COVID\u201019) in outpatient setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this triple\u2010blind randomized placebo\u2010controlled clinical trial, sixty mild to moderate COVID\u201019 patients in outpatient setting who fulfilled the inclusion criteria were randomly allocated to treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) group to receive oral nanocurcumin formulation (Sinacurcumin soft gel which contains 40\u00a0mg curcuminoids as nanomicelles), two soft gels twice a day after food for 2\u00a0weeks or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) group. Patients\u2019 symptoms and laboratory data were assessed at baseline and during follow\u2010up period and compared between two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All symptoms except sore throat resolved faster in the treatment group and the difference was significant for chills, cough and smell and taste disturbances. The CRP serum level was lower in the treatment group at the end of two weeks and the lymphocyte count was significantly higher in treatment group. No significant adverse reaction reported in the treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral nanoformulation of curcumin can significantly improve recovery time in patients with mild to moderate COVID\u201019 in outpatient setting. Further studies with larger sample size are recommended.<\/jats:p><\/jats:sec>","DOI":"10.1002\/fsn3.2226","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T13:57:10Z","timestamp":1624111030000},"page":"4068-4075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Oral nano\u2010curcumin formulation efficacy in the management of mild to moderate outpatient COVID\u201019: A randomized triple\u2010blind placebo\u2010controlled clinical trial"],"prefix":"10.1002","volume":"9","author":[{"given":"Reza","family":"Ahmadi","sequence":"first","affiliation":[{"name":"Department of Family Medicine School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soofia","family":"Salari","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Davood","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Emergency Medicine Mashhad University of Medical sciences Mashhad Iran"},{"name":"Department of Internal Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Reihani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Emergency Medicine Mashhad University of Medical sciences Mashhad Iran"},{"name":"Department of Internal Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Bagher","family":"Rostamiani","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Behmadi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Emergency Medicine Mashhad University of Medical sciences Mashhad Iran"},{"name":"Department of Internal Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhila","family":"Taherzadeh","sequence":"additional","affiliation":[{"name":"Targeted Drug Delivery Research Center School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Eslami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Informatics Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mahdi","family":"Rezayat","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Reza","family":"Jaafari","sequence":"additional","affiliation":[{"name":"Nanotechnology Research Center Pharmaceutical Technology Institute Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Department of Pharmaceutical Nanotechnology School of Pharmacy Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9857-1175","authenticated-orcid":false,"given":"Sepideh","family":"Elyasi","sequence":"additional","affiliation":[{"name":"Department of Family Medicine School of Medicine Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0606-7"},{"key":"e_1_2_9_3_1","article-title":"Curcumin as a potential treatment for COVID\u201019","author":"Airton Castro Rocha F. A.","year":"2020","journal-title":"Phytotherapy Research"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111699"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.09.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1060-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1858"},{"issue":"2","key":"e_1_2_9_8_1","first-page":"1","article-title":"Induction of pro\u2010inflammatory cytokines (IL\u20101 and IL\u20106) and lung inflammation by Coronavirus\u201019 (COVI\u201019 or SARSCoV\u20102): Anti\u2010inflammatory strategies","volume":"34","author":"Conti P.","journal-title":"J Biol Regul Homeost"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01061-20"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874471013666191223152658"},{"issue":"3","key":"e_1_2_9_12_1","first-page":"282","article-title":"Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids","volume":"22","author":"Hatamipour M.","year":"2019","journal-title":"Iran J Basic Med Sci."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.230383"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.768986"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2019.1650914"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25030689"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000508"},{"issue":"5","key":"e_1_2_9_19_1","first-page":"567","article-title":"The effect of nano\u2010curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: A randomized clinical trial","volume":"6","author":"Rahimi H. R.","year":"2016","journal-title":"Avicenna J Phytomed"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46401-5_9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30304-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2020.101623"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6766"},{"key":"e_1_2_9_24_1","first-page":"1","article-title":"Oral nano\u2010curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease\u201019 patients: An open label nonrandomized clinical trial","author":"SaberMoghaddam N.","year":"2021","journal-title":"Phytotherapy Research"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2568"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.42.24995"},{"key":"e_1_2_9_27_1","article-title":"Immunomodulatory effects of Nanocurcumin on Th17 cell responses in mild and severe COVID\u201019 patients","volume":"1","author":"Tahmasebi S.","year":"2020","journal-title":"Journal of Cellular Physiology"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107088"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280215588241"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0994"},{"key":"e_1_2_9_31_1","first-page":"1","article-title":"Potential effects of curcumin in the treatment of COVID\u201019 infection","author":"Zahedipour F.","year":"2020","journal-title":"Phytotherapy Research"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/186864"}],"container-title":["Food Science &amp; Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.2226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/fsn3.2226","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.2226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T07:55:19Z","timestamp":1693295719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/fsn3.2226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,19]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/fsn3.2226"],"URL":"https:\/\/doi.org\/10.1002\/fsn3.2226","archive":["Portico"],"relation":{},"ISSN":["2048-7177","2048-7177"],"issn-type":[{"value":"2048-7177","type":"print"},{"value":"2048-7177","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,19]]},"assertion":[{"value":"2021-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}