{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:00:24Z","timestamp":1791828024412,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Based on the anti\u2010inflammatory and antihypertensive properties of garlic, the current study was designed to evaluate the garlic powder effects on blood pressure and high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) among Nonalcoholic Fatty Liver Disease patients (NAFLD). This randomized, double\u2010blind, placebo\u2010controlled trial study was conducted on 110 patients with NAFLD. The patients were randomly divided into 2 groups, receiving two tablets of either 400\u00a0mg garlic or placebo daily for 15\u00a0weeks. At baseline and the end of the study, blood pressure and hs\u2010CRP were determined. Of 110 patients enrolled in the trial, 98 subjects were included in the final analysis. After the intervention, systolic blood pressures (SBP) (mean: \u22127.89; 95%CI:\u201211.39 to \u22124.39\u00a0mm Hg), diastolic blood pressure (DBP) (mean: \u22125.38; 95%CI: \u22127.77 to \u22123\u00a0mm Hg), and Mean Arterial Pressure (MAP) (mean: \u22126:95%CI: \u22128.4 to \u22123.6\u00a0mm Hg) decreased significantly in the garlic group as compared to the placebo group. Also, the percentage of reduced hs\u2010CRP was significantly higher in the intervention group compared with the control group (mean: \u221216.1; 95%CI: \u221232.7 to \u22120.53;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.035). Moreover, a positive correlation was observed between the percentage change in hs\u2010CRP and percentage changes in SBP (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.221;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.029), DBP (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.166;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.012), and MAP (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.210;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.038). Garlic supplementation can be a safe and potentially adjunct treatment to reduce blood pressure and the risk of cardiovascular disorders in patients with NAFLD.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.2307","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T11:58:34Z","timestamp":1620388714000},"page":"3556-3562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of garlic powder supplementation on blood pressure and hs\u2010C\u2010reactive protein among nonalcoholic fatty liver disease patients: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-3743","authenticated-orcid":false,"given":"Davood","family":"Soleimani","sequence":"first","affiliation":[{"name":"Nutritional Sciences Department School of Nutrition Sciences and Food Technology Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh","family":"Parisa Moosavian","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition School of Nutrition and Food Sciences Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Zolfaghari","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zamzam","family":"Paknahad","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition School of Nutrition and Food Sciences Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/201010581102000213"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00724.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.12.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032804"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-010-0037-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520000124"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.005"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31338-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.20474"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.7.2171"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073877"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_887_19"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172666"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.171"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030853"},{"issue":"2","key":"e_1_2_11_17_1","first-page":"116","article-title":"Effects of garlic on brachial endothelial function and capacity of plasma to mediate cholesterol efflux in patients with coronary artery disease","volume":"18","author":"Mahdavi\u2010Roshan M.","year":"2017","journal-title":"The Anatolian Journal of Cardiology"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6723"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049286"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L319"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003233421202"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/IBPC.S51434"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-8-13"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00122"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/678159"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S254555"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6225"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.12.013"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2014.12.013"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00384-0"}],"container-title":["Food Science &amp; 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