{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:03:37Z","timestamp":1767135817962,"version":"build-2238731810"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Soy isoflavones (SI) have strong estrogenic effect in tissues by binding to estrogen receptors and might be beneficial for women with polycystic ovarian syndrome (PCOS) by reduction in testosterone, cholesterol, insulin, weight gain, inflammatory markers, and oxidative stress. The study was planned to examine the effect of various levels of SI on nutrient intake, digestibility, lipid profile, insulin, and reproductive hormones of estradiol valerate (4\u00a0mg\/rat\/IM) PCOS induced rat models. Thirty\u2010six Wistar 45\u00a0days old rats weighing 95\u00a0\u00b1\u00a05\u00a0g were divided into 4 groups, each having 9 rats: C (control: without SF), SF10 (SF 0.10\u00a0g\/kg BW), SF15 (SF 0.15\u00a0g\/kg BW), and SF20 (SF 0.20\u00a0g\/kg BW). SF was given through the oral gavage. Food and water were offered ad libitum, and intake was recorded daily. During last week of trial, collected feces by total collection method and blood samples were used to calculate nutrient digestibility and biochemical analysis, respectively. Estrogen, progesterone, and prolactin were (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.05) high in rats fed SF diet that was 4% and 30% increase from C, respectively. Insulin, testosterone, FSH, and LH were lowest in rats fed diet SF20. Significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.05) reduction in cholesterol was observed in rats fed SF15 and SF20 as compared to C. Serum HDL was improved (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.05) in all SIF\n                    <jats:sub>0.10<\/jats:sub>\n                    , SIF\n                    <jats:sub>0.15,<\/jats:sub>\n                    and SIF\n                    <jats:sub>0.20<\/jats:sub>\n                    in comparison with PC. Serum LDL was significantly reduced to 68.89\u00a0\u00b1\u00a04.36 (mg\/dl) in SIF\n                    <jats:sub>0.20<\/jats:sub>\n                    and to 108.20\u00a0\u00b1\u00a04.14 (mg\/dl) in SIF\n                    <jats:sub>0.15,<\/jats:sub>\n                    whereas insignificant reduction was observed in SIF\n                    <jats:sub>0.10<\/jats:sub>\n                    as compared to PC. Highly significant reduction was noted in triglycerides level in SIF\n                    <jats:sub>0.20;<\/jats:sub>\n                    however, significant reduction was observed in both SIF\n                    <jats:sub>0.10<\/jats:sub>\n                    and SIF\n                    <jats:sub>0.15<\/jats:sub>\n                    as compared to PC after 3\u00a0months of treatment with soy isoflavones.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.2322","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T09:30:50Z","timestamp":1625823050000},"page":"4738-4744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["RETRACTED: Exploring the prophylactic role of soy isoflavones against polycystic ovarian syndrome"],"prefix":"10.1002","volume":"9","author":[{"given":"Nishaf","family":"Manzar","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences Government College University Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safwan Ahmad","family":"khan","sequence":"additional","affiliation":[{"name":"Basic Health Unit (BHU) Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najum","family":"Fatima","sequence":"additional","affiliation":[{"name":"District Head Quarter Hospital Chiniot Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehr un","family":"Nisa","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences Government College University Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Haseeb","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Food Science Faculty of Life Sciences Government College University Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Inam","family":"Afzal","sequence":"additional","affiliation":[{"name":"Department of Biosciences COMSATS University Islamabad Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiz Fahad Ullah","family":"Saeed","sequence":"additional","affiliation":[{"name":"King Edward Medical University Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of Diet and Nutritional Sciences University of Lahore Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faqir Muhammad","family":"Anjum","sequence":"additional","affiliation":[{"name":"Vice Chancellor Secretariat University of the Gambia Banjul The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-886X","authenticated-orcid":false,"given":"Muhammad Sajid","family":"Arshad","sequence":"additional","affiliation":[{"name":"Department of Food Science Faculty of Life Sciences Government College University Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2010.10.002"},{"key":"e_1_2_8_3_1","first-page":"115","article-title":"Clinical Investigation of triglycerides","volume":"9","author":"Annoni G. 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