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This study aimed to explore the impact of n\u20103 PUFA\u2010enriched fish oil (n\u20103 PUFA\u2010FO) on UVB\u2010induced sunburns and subsequent healing. Sixty C57BL\/6 female mice were divided into two groups. The treated group mice were fed n\u20103 PUFA\u2010FO for the entire duration of the experiment. Mice in the control group were fed a standard diet. After two weeks of n\u20103 PUFA\u2010FO feeding, mice were exposed to UVB for 20\u00a0min and sacrificed 20 d later. Skin photodamage and lesion area were recorded during wound healing. Epidermal lesion thickness was quantified in hematoxylin and eosin\u2010stained skin sections. Inflammation and macrophage polarization were assessed by qRT\u2010PCR. Oxidative stress and antioxidant enzyme activity were quantified using specific ELISA kits. N\u20103 PUFA\u2010FO feeding decreased UVB photodamage and accelerated wound healing progression, both of which were coupled with less intense inflammation and increased macrophage M2 phenotype polarization. Furthermore, n\u20103 PUFA\u2010FO brought about a decrease in malondialdehyde (MDA) levels but increased the activity of catalase (CAT) and glutathione peroxidase (GP), without changing superoxide dismutase (SOD) activity. N\u20103 PUFA\u2010FO protects against UVB\u2010induced skin photodamage and promotes wound healing by modulating macrophage phenotypic polarization and antioxidant enzyme activities. N\u20103 PUFA\u2010FO could be a novel therapeutic approach for both the prevention and treatment of sunburns.<\/jats:p>","DOI":"10.1002\/fsn3.2330","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T15:22:12Z","timestamp":1621264932000},"page":"3693-3700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dietary supplementation with N\u20103 polyunsaturated fatty acid\u2010enriched fish oil promotes wound healing after ultraviolet B\u2010induced sunburn in mice"],"prefix":"10.1002","volume":"9","author":[{"given":"Fanxing","family":"Meng","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Jilin Agricultural University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Sciences Po Paris 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