{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:53:53Z","timestamp":1792518833787,"version":"4.5.0"},"reference-count":94,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In the present study, the aerial parts of\n                    <jats:italic>Achyranthes ferruginea<\/jats:italic>\n                    underwent investigation of their in vitro antioxidant and free radical\u2010scavenging activities in cell\u2010free conditions, their phytoconstituents using gas chromatography\u2010mass spectrometry (GC\u2010MS), and their cytotoxic activity in HeLa cells.\n                    <jats:italic>A.\u00a0ferruginea<\/jats:italic>\n                    was extracted with 80% methanol and successively fractionated with solvents to yield petroleum ether (PEF), chloroform (CHF), ethyl acetate (EAF), and aqueous (AQF) fractions. GC\u2010MS analysis revealed that CHF contained ten phytoconstituents, including different forms of octadecanoic acid methyl esters. The total antioxidant and ferric\u2010reducing antioxidant capacities of the extracts and the standard catechin (CA) were as follows: CA &gt;CHF &gt;PEF &gt;CME (crude methanolic extract) &gt;EAF &gt;AQF, and CA &gt;CHF &gt;EAF &gt;PEF &gt;AQF &gt;CME, respectively. CHF showed the highest DPPH\u2010free radical\u2010scavenging activity, with a median inhibitory concentration of 10.5\u00a0\u00b1\u00a00.28\u00a0\u00b5g\/ml, which was slightly higher than that of the standard butylated hydroxytoluene (12.0\u00a0\u00b1\u00a00.09\u00a0\u00b5g\/ml). In the hydroxyl radical\u2010scavenging assay, CHF showed identical scavenging activity (9.25\u00a0\u00b1\u00a00.73\u00a0\u00b5g\/ml) when compared to CA (10.50\u00a0\u00b1\u00a01.06\u00a0\u00b5g\/ml). Moreover, CHF showed strong cytotoxic activity (19.95\u00a0\u00b1\u00a01.18\u00a0\u00b5g\/ml) in HeLa cells, which was alike to that of the standards vincristine sulfate and 5\u2010fluorouracil (15.84\u00a0\u00b1\u00a01.64\u00a0\u00b5g\/ml and 12.59\u00a0\u00b1\u00a01.75\u00a0\u00b5g\/ml, respectively). The in silico study revealed that identified compounds were significantly linked to the targets of various cancer cells and oxidative enzymes. However, online prediction by SwissADME, admetSAR, and PASS showed that it has drug\u2010like, nontoxic, and potential pharmacological actions.\n                  <\/jats:p>","DOI":"10.1002\/fsn3.2343","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T21:37:56Z","timestamp":1622583476000},"page":"3777-3805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of\n                    <i>Achyranthes ferruginea<\/i>\n                    Roxb. in cancer cell line"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-0245","authenticated-orcid":false,"given":"A. S. M. 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Samima","family":"Nasrin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mahbubur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Varendra University Rajshahi Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu Montakim","family":"Tareq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zidan","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamunur","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Rajshahi Rajshahi Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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