{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:23:10Z","timestamp":1792873390483,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Blumea lacera<\/jats:italic> is an edible plant with imperative medicinal values. However, the anxiolytic and antidepressant roles of <jats:italic>B. lacera<\/jats:italic> have not been well\u2010explained. Therefore, the current study aims to explore the impending bioactive metabolites and roles of <jats:italic>B. lacera<\/jats:italic> methanol leaf extract (Me\u2010BLL) in attenuating anxiety and depression through several experimental and computer\u2010aided approaches. The chemical characterization of Me\u2010BLL was performed through standard phytochemical and GC\u2010MS analyses. To explore the neuropharmacological insights, Swiss albino mice were treated with Me\u2010BLL at doses of 200\u2013400\u00a0mg\/kg, p.o. The anxiolytic effects were observed employing elevated plus maze (EPM), light\u2013dark box (LDB), and hole\u2010board (HBT) tests, while antidepressant effects were evaluated using forced swimming (FST) and tail suspension tests (TST). Diazepam (1\u00a0mg\/kg, i.p.) and fluoxetine HCl (20\u00a0mg\/kg, p.o.) were used as the reference standard. The phytochemical analyses revealed several bioactive metabolites, including higher contents of total phenolics and flavonoids. The EPM and LDB tests demonstrated an increased time spent in open arms and light box, and the HBT showed an increased number of head dipping, indicating the anxiolytic effects of Me\u2010BLL. The TST and FST revealed a decrease in immobility time, meaning the persuasive antidepressant effects. The antioxidative effects of Me\u2010BLL have also been observed prominently. Correspondingly, the computer\u2010aided investigation confirmed several bioactive lead molecules. Specifically, thymol and cuminol revealed potential anxiolytic and antioxidant effects, while stigmast\u20105\u2010en\u20103.beta.\u2010ol and gamma\u2010sitosterol possessed promising antidepressant effects. Taken these results as a base, the plant has imperative potentials in managing anxiety and depression\u2010like disorders.<\/jats:p>","DOI":"10.1002\/fsn3.2362","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T17:03:22Z","timestamp":1622480602000},"page":"3836-3851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Bioactive metabolites of <i>Blumea lacera<\/i> attenuate anxiety and depression in rodents and computer\u2010aided model"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2850-1635","authenticated-orcid":false,"given":"Md. Amjad","family":"Hossen","sequence":"first","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-0245","authenticated-orcid":false,"given":"A.S.M.","family":"Ali Reza","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh"},{"name":"Department of Biochemistry and Molecular Biology Faculty of Biological Sciences University of Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Badrul","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mst. Samima","family":"Nasrin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh"},{"name":"Department of Biochemistry and Molecular Biology Faculty of Biological Sciences University of Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawhidul Amin","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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