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The resulting tissue hydrolyzate of the chicken embryo (CETH) has been evaluated for acute toxicity and tested against chronic arthritis induced by Freund's full adjuvant (modified Mycobacterium butyricum) in rats. The antiarthritic effect of CETH was studied on the 28th day of the experiment after 2\u00a0weeks of oral administration of CETH at doses of 60 and 120\u00a0mg\/kg body weight. Arthritis was evaluated on the last day of the experiment on the injected animal paw using X\u2010ray computerized microtomography and histopathology analysis methods. The CETH effect was compared with the non\u2010steroidal anti\u2010inflammatory drug diclofenac sodium (5\u00a0mg\/kg). Oral administration of CETH was accompanied by effective dose\u2010dependent correction of morphological changes caused by the adjuvant injection. CETH had relatively high recovery effects in terms of parameters for reducing inflammation, inhibition of osteolysis, reduction in the inflammatory reaction of periarticular tissues, and cartilage degeneration. This study presents for the first time that CETH may be a powerful potential nutraceutical agent or bioactive component in the treatment of rheumatoid arthritis.<\/jats:p>","DOI":"10.1002\/fsn3.2529","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T05:18:31Z","timestamp":1629350311000},"page":"5648-5669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Anti\u2010arthritic effect of chicken embryo tissue hydrolyzate against adjuvant arthritis in rats (X\u2010ray microtomographic and histopathological analysis)"],"prefix":"10.1002","volume":"9","author":[{"given":"Igor","family":"Rzhepakovsky","sequence":"first","affiliation":[{"name":"Institute of Live Science North Caucasus Federal University Stavropol Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahida","family":"Anusha Siddiqui","sequence":"additional","affiliation":[{"name":"Technical University of Munich Campus Straubing for Biotechnology and Sustainability Straubing Germany"},{"name":"DIL e.V. 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