{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T23:48:36Z","timestamp":1769212116720,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Food Science &amp; Nutrition"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Scope<\/jats:title><jats:p>This study was carried out to investigate the efficacy of a new combination of root extracts of the <jats:italic>Lepidium meyenii<\/jats:italic> (maca) plant, known for its nutritional and energizing features as well as its antioxidant properties, on nutrient digestibility and nutrient transporters expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A total of 28 Sprague\u2010Dawley rats (8\u2010week\u2010old) were divided into four groups: (i) control, (ii) <jats:italic>Lepidium m<\/jats:italic>., (iii) high\u2010fat diet (HFD), and (iv) HFD+<jats:italic>Lepidium m<\/jats:italic>. Maca was given to the rats as a powdered combination of the plant roots with a daily dose of 40\u00a0mg per kg BW. Maca administration significantly increased the digestibility of dry matter (DM), organic matter (OM), crude protein (CP), and ether extract (EE), and some nutrient transporter (Pept1\/2, Fatp1, Glut1\/2, and Sglt1)\u2010expressions compared with non\u2010treated control and HFD groups in the jejunum and ileum tissues (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maca supplementation improved the digestibility of nutrients and expressions of nutrient transporters in the small intestine of the rats. These results indicate the positive communication between maca consumption and nutrient absorption in the small intestines of the animals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/fsn3.2545","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T18:21:42Z","timestamp":1630434102000},"page":"5765-5773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of maca (<i>Lepidium meyenii<\/i>) on nutrient digestibility and major nutrient transporters in rats fed a high\u2010fat diet"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-1154","authenticated-orcid":false,"given":"Nurhan","family":"Sahin","sequence":"first","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Disorders Faculty of Veterinary Medicine Firat University Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4138-7689","authenticated-orcid":false,"given":"Cemal","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Disorders Faculty of Veterinary Medicine Firat University Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7716-552X","authenticated-orcid":false,"given":"Hasan","family":"Gencoglu","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Firat University Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9583-2218","authenticated-orcid":false,"given":"Besir","family":"Er","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Firat University Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8781-8838","authenticated-orcid":false,"given":"Ibrahim H.","family":"Ozercan","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Firat University Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2399-838X","authenticated-orcid":false,"given":"James R.","family":"Komorowski","sequence":"additional","affiliation":[{"name":"Research and Development Nutrition21 LLC Harrison NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-5244","authenticated-orcid":false,"given":"Kazim","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Nutritional Disorders Faculty of Veterinary Medicine Firat University Elazig Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Official methods of analysis","author":"AOAC","year":"1990"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.08.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/microarrays6020007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010018\u20100126\u2010x"},{"key":"e_1_2_11_6_1","volume-title":"StatPearls","author":"Collins J. 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